过量饮用乙醇对睾丸超微结构的影响.pdfVIP

第 38 卷　第 3 期 青 岛 大 学 医 学 院 学 报 Vol. 38 , No. 3 2002 年 9 月 ACTA ACADEMIAE MEDICINAE QIN GDAO UNIVERSITATIS September 　2002 过量饮用乙醇对睾丸超微结构的影响 1 2 赵 　蓉 　李 　玲 [摘要] 　①目的 　探讨过量饮酒对睾丸超微结构的影响。②方法 　给成年雄性昆明小白鼠喂饲饮用酒 ,剂量 为每天 4 g/ kg 体质量 ,连用 5 d ,透射电镜观察睾丸曲精小管及间质细胞的超微结构改变。③结果 　实验组睾丸生 精上皮细胞层数减少 ,细胞间紧密连接破坏 ;生精细胞及支持细胞分裂象减少 ,凋亡数量增多 ; 间质细胞退行性变 乃至凋亡。④结论 　乙醇可影响生精过程。 [ 关键词] 　睾丸 ;醇 , 乙;显微镜检查 , 电子;小鼠 [ 中图分类号] 　Q954. 43 + 4 　　[文献标识码] 　A 　　[文章编号] (2002) INFL UENCE OF ALCOHOL OVERTAKING ON THE ULTRAMICROSCOPIC STRUCTURE OF THE TESTIS 　ZHA O Rong , L I L i ng 　Department of Human Parasitolo gy , Qingdao University Medical College , Qingdao 266021 [ ABSTRACT] 　 Objective 　To study the influence of overtaking of liquor on the ultramicroscopic structure of the testis. Methods 　Adult male Kunming mice were given liquor through the stomach , the amount being 4g/ kg body weight per day for 5 consecu tive days. The ultramicroscopic changes of the convoluted seminiferous tubules and the interstitial cells were investigated under the elec tronic microscope. 　Results 　In the experimental group , the layers of the spermproducing cells of the testis decreased , tight junctions between cells were destroyed , the mitosis of spermproducing cells and supporting cells decreased , the number of apoptosis increased , and the interstitial cells deteriorated and died. 　Conclusion 　Alcohol can influence the process of sperm production. [ KEY WORDS] 　testis ; alcohol ; microscopic examination ; electron ; mouse 　　目前关于男性生殖方面的研究已受到广泛关 2 　结 　　果 注 ,有学者对重金属、细胞毒药物及免疫抑制剂、生 殖激素等对精子发生的影响作了深入的研究[1 ,2 ] 。