mTOR信号传导通路及运动对其影响的分子机制综述.pdfVIP

第15卷第6期 体 育 学 刊 Vol.15 No.6 2008 年 6 月 Journal of Physical Education Jun.2008 mTOR信号传导通路及运动对其影响的分子机制综述 29 （华东师范大学体育与健康学院，上海 200241 ） 摘 要：mTOR mTOR 4 (2 mTOR 2 mTOR ) mTOR PI3K/Akt/mTOR PI3K/Akt/TSC12/mTOR AMPK/TSC2/mTOR 关 键 词： 中图分类号：G804.7 文献标识码：A 文章编号：1006-7116(2008)06-0108-05 mTOR signal conduction paths and their motion affecting molecular mechanism ZHAO Xian ，LI Shi-chang ，LI Xiao-ying （School of Physical Education and Health，East China Normal University ，Shanghai 200241，China ） Abstract: By working on the molecular structure of mTOR, the authors gave an overview of 4 signal conduction paths (2 mTOR upstream signal paths and 2 mTOR downstream signal paths) that base their center on mTOR. These signal paths play a critical role in the process of signal conduction of motion affecting the skeletal muscle. All these signal systems that cause the change of quality of the skeletal muscle are basing their center on mTOR, and interac- tively connected to form a unified signal conduction network. On the one hand, kinetic skeletal muscle hypertrophy is affected by such two paths as PI3K/Akt/mTOR and PI3K/Akt/TSC12/mTOR; on the other hand, kinetic skeletal muscle atrophy is affected by such a signal conduction path as AMPK/TSC2/mTOR. Key words: mTOR ；signal conduction；skeletal muscle；molecule mechanism ；overview