Elevated peroxidative glutathione redox status in atherosclerotic patients with increased thickness of carotid intima media.pdfVIP

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Elevated peroxidative glutathione redox status in atherosclerotic patients with increased thickness of carotid intima media.pdf

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Elevated peroxidative glutathione redox status in atherosclerotic patients with increased thickness of carotid intima media.pdf

ChineseMedicalJourna2009,’122(23)．2827-2832 2827 Originalarticle Elevatedperoxidativeglutathioneredoxstatusinatherosclerotic patientswithincreasedthicknessofcarotidintimamedia HUANGYan—sheng，W ANG Li—xia，SUN Lin，W U Y_u，LU Jian—rain，ZHAO Shi—chao，DAIFu—min， XU Bo—shiandWANG Shu．ren Keywords：atherosclerosis；redoxstatus；glutathionenicotinamide；adeninedinucleotidephosphate low densi~ lipoprotein，oxidized Background Atherosclerosisjsachronicinflammatorydisease．Accumulatedevidencessuggestadeepjnvolvement ofoxidativedamageinthedevelopmentofatherOscIerOsis．butIittleisdiscussedovertherelationshipbetweenplasma glutathioneredoxstatusasthemostimpo~antintrinsicantioxidantdefensivemechanism andthea竹1erOscIerOSis． Methods A totaJof132patientssuspected with atherosclerosiswereassigned to three groupsbyhigh frequency ultrasonicexaminationofthe carotidartery．W iththethicknessofintlmaofthecarotidartery asanindexofdegreeof atherosclerosisprogression，56wereincludedinplaque—forminggroup(A)，42incarotidarteryintima-thickeninggroup (B)，and34innom1alcarotidarteryintima．thicknessgroup(C)．Allpatientsweresubjectedtothemeasurementofplasma glutathione(GSH)(reducedf0rmGSHandoxidizedformGSSG)，nicotinamideadeninedinucleotidephosphate(NADP) (reducedformNADPHandoxidizedformNADP)，oxidizedIowdensitylipoprotein(oxLDL)，andmalondiaIdehyde(MDA) The GSH／GSSG and NADPH／NADP redoxpotentialswere calculated according to theNernstequation，and their correlationwithintimathicknessandoxLDLwasanalyzed． Results Withthethickeningofarteryinlima (from groupC toA)，GSH concentrationandtheratioofGSH／GSSG graduallyreduced，andGSSGandGSH／GSSGredoxpotentialgraduallyincreased(morepositive)(P0．o5)．The NADPH andNADPH／NADP redoxstatusalso showed similarbutmilderchanges．Theproductsofoxidativestress oxLDLandMDA increasedsignificantlyalongwiththethickeningofarteryintimafPO