环境污染物发育毒性机制研究系统生物学方法进展.pdfVIP

2011 6 Vo l. 6, 20 11 1 , 2330 Asian Jour nal of Ecot ox icolo gy N o. 1, 2330 1, 2 1 1 1, * 徐挺 , 赵静 , 胡霞林 , 尹大强 1. 同济大学环境科学与工程学院长江水环境教育部重点实验室, 上海 200092 2 . 安徽大学资源与环境工程学院环境科学研究所, 肥 230601 : ( g ene r egulato ry netw or k , GR N , , , , , : ; ; : 167 35 897( 20 11 602308 : X 17 1. 5 : A Review of Systems Biology Approach to Study on Developmental Toxicity Mechanism of Environmental Pollutants 1, 2 1 1 1, * Xu T ing , Zh ao Jing , H u X ialin , Y in Daqiang 1. K ey L abor ator y o f Yang tze R iver Water Env ir onment , M inistr y of Educatio n, Colleg e of Environment al Science and Engineer ing, T ongji U niversit y, Shanghai 200092, China 2 . Institute of Envir onmenta l Science, Scho ol o f R eso ur ces and Env ir onmental Eng ineer ing, Anhui U niv ersit y, H ef ei 23060 1, Chi na Received 11 A ugu st 2010 accepted1 Oct ober 2010 Abstract Gene regulato ry netw or k ( GR N was a nov el syst em at ical biolog y approach f or the st udy on gene regulat ion mechanism, especially helpf ul in describing the early development of animal body. Because G RN s can present the net w orks and dy nam ics of regulat or y processing, and t he t rue impacts f rom t he environment al per turbat ion , they w ere ex pect ed t o play a key ro le in st udy ing developm ent al t oxicity mechanisms of environ mental po llut ant s including endo crine disrupt ing chemicals w it h r esolving many problems w hich exist ed f or a lo ng t ime. T he st ruct ures, met hodo logies, cur rent applicatio n cases of G RN s are r ew iew ed. T he application of G RN s int o mechanism researches of dev elo pmental t oxicity of pollut ant s is pr