文献_2011-Association of FMR1 Genotypes with In Vitro Fertilization (IVF) Outcomes Based on Ethnicity Race.pdfVIP

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文献_2011-Association of FMR1 Genotypes with In Vitro Fertilization (IVF) Outcomes Based on Ethnicity Race.pdf

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Association of FMR1 Genotypes with In Vitro Fertilization (IVF) Outcomes Based on Ethnicity/Race 1,2 1,3 1 1,4 Norbert Gleicher *, Andrea Weghofer , Irene H. Lee , David H. Barad * 1 Center for Human Reproduction (CHR) and Foundation for Reproductive Medicine, New York, New York, United States of America, 2 Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, United States of America, 3 Department of Gynecological Endocrinology and Reproductive Medicine, Vienna University School of Medicine, Vienna, Austria, 4 Department of Epidemiology and Social Medicine and Department of Obstetrics, Gynecology and Women’s Health, Albert Einstein College of Medicine, Bronx, New York, United States of America Abstract The FMR1 gene, mapping to an area of the X chromosome closely associated with autoimmunity also affects ovarian reserve, with specific genotypes associated with distinct ovarian aging patterns. They, therefore, could also be associated with differences of in vitro fertilization (IVF) outcomes, reported between races/ethnicities. We analyzed 339 consecutive IVF patients, 232 Caucasian, 59 African and 48 Asian, for FMR1 genotypes, and tested by multiple logistic regressions for associations between race/ethnicity, FMR1 genotype, autoimmunity and pregnancy chances with IVF. FMR1 genotypes were predictive of pregnancy (P = 0.046), het-norm/low most significantly and with decreasing chance in comparison to norm genotypes (OR 0.44; 95% CI 0.23–0.85; P = 0.014). Race/ethnicity was, overall, independently associated (P = 0.03), African demonstrating decreased odds in comparison to Caucasian (OR 0