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文献_2012-Impaired Gremlin 1 (GREM1) expression in cumulus cells in young women with diminished ovarian reserve (DOR).pdf

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J Assist Reprod Genet (2012) 29:159– 162 DOI 10.1007/s10815-011-9684-8 GONAD PHYSIOLOGY AND DISEASE Impaired Gremlin 1 (GREM1) expression in cumulus cells in young women with diminished ovarian reserve (DOR) Sangita Jindal Keri Greenseid Dara Berger Nanette Santoro Lubna Pal Received: 29 July 2011 /Accepted: 20 November 2011 /Published online: 11 December 2011 # Springer Science+Business Media, LLC 2011 Abstract Methods We measured gremlin 1 (GREM1) gene expression Purpose A symbiotic relationship between ovarian granu- in GC’s from infertile women 38 years undergoing in vitro losa cells (GC) and the developing oocyte is critical. fertilization in the context of DOR. Genetic modulations in GC’s can lead to reproductive Results GREM1, a member of the differential screening- insufficiency, highlighting the role of GC’s in reproduc- selected gene aberrative in neuroblastoma (DAN) family tive competence. Utilizing gene expression analyses in of genes known for its highly regulated expression pattern cumulus GC’s, we attempt to enhance our understanding during folliculogenesis and a downstream effecter of oocyte- of mechanisms that may contribute to poor reproductive derived growth and differentiation factor 9, was down- capacity in young women with diminished ovarian reserve regulated 3-fold (−3.08) in women with DOR versus control; (DOR). down-regulation was confirmed by qRT-PCR (−4.02). All research was performed in the Division of REI, Department of Obstetrics, Gynecology Women’s Health, Albert Einstein College of Medicine, Bronx, NY and Montefiore ’s Institute for Reproductive Medicine and Health, Hartsdale, NY. A portion