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Arthritis Care Research
Vol. 64, No. 10, October 2012, pp 1431–1446
DOI 10.1002/acr.21772
© 2012, American College of Rheumatology
SPECIAL ARTICLE
2012 American College of Rheumatology
Guidelines for Management of Gout. Part 1:
Systematic Nonpharmacologic and Pharmacologic
Therapeutic Approaches to Hyperuricemia
DINESH KHANNA,1 JOHN D. FITZGERALD,2 PUJA P. KHANNA,1 SANGMEE BAE,2 MANJIT K. SINGH,3
TUHINA NEOGI,4 MICHAEL H. PILLINGER,5 JOAN MERILL,6 SUSAN LEE,7 SHRADDHA PRAKASH,2
MARIAN KALDAS,2 MANEESH GOGIA,2 FERNANDO PEREZ-RUIZ,8 WILL TAYLOR,9
´ ´ ´ 10 4 11 12
FREDERIC LIOTE, HYON CHOI, JASVINDER A. SINGH, NICOLA DALBETH,
SANFORD KAPLAN,13 VANDANA NIYYAR,14 DANIELLE JONES,14 STEVEN A. YAROWS,15
BLAKE ROESSLER,1 GAIL KERR,16 CHARLES KING,17 GERALD LEVY,18 DANIEL E. FURST,2
N. LAWRENCE EDWARDS,19 BRIAN MANDELL,20 H. RALPH SCHUMACHER,21 MARK ROBBINS,22
NEIL WENGER,2 AND ROBERT TERKELTAUB7
Guidelines and recommendations developed and/or endorsed by the American College of Rheumatology (ACR) are
intended to provide guidance for particular patterns of practice and not to dictate the care of a particular patient.
The ACR considers adherence to these guidelines and recommendations to be voluntary, with the ultimate determi-
nation regarding their application to be made by the physician in light of each patient’s individual circumstances.
Guidelines and recommendations are intended to promote beneficial or desirable outcomes but cannot guarantee
any specific outcome. Guidelines and recommendations developed or endorsed by the ACR are subject to periodic
revision as warranted by the evolution of medical knowledge, technology, and practice.
The American College of Rheumatology is an independent, professional, medical and scientific society which does
not guarantee, warrant, or endorse any commercial pr
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