MATLAB在医学中应用.pptVIP

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MATLAB在医学中应用.ppt

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Activation Statistics History of Nuclear Magnetic Resonance Physics of protons. Protons aligning within a magnetic field Larmor Frequency Reading M0 Ultrashort MR physics overview Step 1: Put Subject in Big Magnet Step 2: Apply Radio Waves Step 3: Measure Radio Waves The BOLD Contrast BOLD signal The Haemodynamic Response Function (HRF) Physiology of the BOLD signal How does the BOLD reflect the energy demands of the brain? What is SPM?the game of the name Statistical Parametric Mapping …a voxel by voxel hypothesis testing approach reliably identify regions showing a significant experimental effect of interest Type I error significance test at each voxel model voxel data, test parameters no exact prior anatomical hypothesis multiple comparisons General Linear Model Random field theory SPM …the software SPM’99 GUI… SPM features… Spatial realignment, spatial normalisation, segmentation, coregistration, spatial smoothing Statistical voxel by voxel statistical analysis general linear model, generalised for temporal autocorrelation random effects analyses multiple comparisons: Corrected p-values from random field theory plotting results interrogation Utilities image display, CheckReg, rendering, brain extraction, adjusted means, image algebra SPM history… SPMclassic: in-house software @ MRC-CU by Karl Friston Jon Heather released to the emerging functional neuroimaging community in 1991 why freely distribute? community open promote rigour (in emerging field) promote collaboration common analysis framework SPM94+ (SPM95, SPM96, SPM99…) developed under auspices of the Wellcome Department of Cognitive Neurology completely rewritten primary authors Karl Friston, John Ashburner, Andrew Holmes, Jean-Baptiste Poline key collaborator Keith Worsley GUI support SPMweb, SPMhelp, SPMcourse SPM toolboxes SnPM Multivariate unwarp SPM architecture SPM MatLab functions scripts ? basic “toolbox” functions ? macro functions/scripts ? GUI functions i/o primitives external