平阳霉素碘油乳剂动脉栓塞治疗甲亢的实验研究.pdfVIP

TH胶组与PLE组三组间两两比较，术前与术后不同时间T3,几、TSH、血钙水平 差异均无显著性 (P0.05)。光镜病理检查显示:PLE能闭塞甲状腺血管，甲状腺 组织缺血灶性坏死，滤泡变性萎缩，间质纤维增生及淋巴细胞浸润，与PVA及TH 胶所致的病理改变相似;而NS组甲状腺无明显病理改变。 结论:PLE栓塞犬的甲状腺后确能显著消除甲状腺的分泌功能，栓塞效果确 切，术后反应轻，无严重并发症，其栓塞效果与PVA,TH胶无明显差别，是安全 有效的。另一方面PLE价格低廉，容易取得，易经导管注入，操作简单，不粘管， 不透X线，便于透视观察及平片复查，克服了PVA,TH胶等其他栓塞剂的缺点而 具有其独特的优越性，是一种理想的甲亢栓塞剂，值得考虑用于甲亢的介入栓塞 治疗。 关键词:动物;实验;动脉栓塞术;甲亢;平阳霉素:碘油 Abstract Objective:Despiteeffectivetreatmentsforhyperthyroidism,therearepatientswho areunabletotolerate,orchoosenottoacceptcurrenttherapies(oralmedication, radioactiveiodine,orsurgery).Thetechniqueofthyroidarterialembolizationisanew effective,minimallyinvasive,convenientandsafemethodforthetreatmentof hyperthyroidism,whichespeciallyfitintocasesthatmaynotbeamenabletocurrent therapeuticoptions.Embolicagentisanimportantfactortoinfluenceeffectinthis technique.Atpresent,avarietyofembolizingagentshaveboththeiradvantagesand disadvantages.Forexample,PolyvinylAlcohol(PVA)particles,aembolicmicroglobe generallybeingaccepted勿majorityauthors,couldresultincompleteembolizationof themajorityofthyroidglandspermanently.However,italsohasitsownbadsides,such ashighrfictioncoefficient,expensivepriceandsoon.Inaddition,someinvestigations indicatethatembolizingresultofTHglueisgood,butitsnegativeisdiscovered. Therefore,toexplorenew embolicagentsisvery necessaryforinterventional embolizationofhyperthyroidism.Thepu印oseofthisexperimentistostudytheeffects andsafetyofPingyangmycinLipiodolEmulsion(PLE)afterembolizationofthyroid anteries. Methods:Twenty-fourmongreldogswererandomlydividedintofourgroups: PVAgroup,THgroup,PLEgroupandNSgroup.Thesefourdifferentembolicagents wereinjectedseparatetelyintobothanteriorthyroidarteriesofdogsineachgroup. Serum T3,T4,TSHandcalciumweremeasuredindifferentintervalsduringthe experiment.Afteronemonthofarterialembolizationalltheanimalswerekilled MorphologicalchangesoftheembolizedthyroidglandwereobservedwithHEstaining. R