口腔癌患者补硒与初步研究.docVIP

口腔癌患者补硒的初步研究 提要 本研究给于54例经病理证实的口腔癌患者于术前每日补硒900ug，共10d。观察发现血浆硒（Se）和谷胱甘肽过氧化物酶（GSH—Px）活力显著提高，血浆脂质过氧化物（丙二醇MDA）显著降低，作自身对照t检验有显著差异(P0.01)，部分患者口腔肿瘤有不同程度缩小的趋势，大部分患者口腔肿瘤生长出现迟缓和停滞。与同期未补硒的12例口腔癌患者对比，对照组肿瘤生长仍活跃。 关键词 　口腔肿瘤；硒；谷胱甘肽过氧化物酶；脂质过氧化物 中国图书资料分类法分类号　　R739．8 The Effects of Selenium Supplement on Fifty-four Cases with Oral Carcinoma Zhang Haizhong, Liu Chunming, Bu Rongfa , Zhao Lin, Bao Shanfen, Li Zheng Cong Tao (Department of Stomatology , General , Hosptial PLA, Beijing 100853) Abstract The epildemiolologic studies indicated that there was an inverse association betweeblood selenlun level and the morbidity and mortality of rnany types of cancer, Animal experiments also showed that selenium supplement may inhibit oral cancer .In this srudy fifty-four patients with oral cancer confirmed by Pathologic examinations were suppfemented with 900μg of selenium dai- ly，for ten days in the pre-operative period．We found plasma selenium（Se）and the activity of plasma glutathione peroxidase（GSH－Px）increased snificantly and the concertralions of lipid peroxides（MDA）decteased afler lreatmenl．With the paired comparision, a statistically slgnlfi- cant differsce (P＜0.01) was found．The tumor mass decreaed in some degree in somepatients. Key words mouth neoplasms; selenium；glutathone peroxidase; lipid peroxides 流行病学研究显示：很多类型的肿瘤的发生率和死亡率与血硒浓度呈负相关[1~3]。动物验发现，硒对口腔癌有抑制作用[4]。 1 对象与方法 1.1 对象 66例口腔癌患者，均为首次就诊。由活检病理证实，56例为鳞癌，9例腺 10 ml的试管，抽取 lml在原子双通道测量 D 样囊性癌，l例恶性黑色素瘤。平均年龄 55.3（40～78）岁。男45例，女21例。测量肿瘤大小，记录数据。随机分为两组，补硒 组54例，对照组12例。 1.2 取材 患者在服硒前空腹抽取静脉血。经处理后测量血浆硒和谷胱甘肽过氧化物酶（GSH—Px）。与补硒10 d后作对比。 1.3 方法 血浆硒含量的测定，采用原子火焰吸收法[5]；精确吸取血浆lml，加人 4 ml 硝酸和 lml高氨酸，在 3500 W