广东省普通人群非酒精性脂肪性肝病患病率的流行病学调查.docVIP

广东省非酒精性脂肪肝患病率调查 周永健1李瑜元1,聂玉强1马金香2石胜利1 　　广州市第一人民医院消化内科1510180） 广州医学院预防医学系2广州市医院消化内科3背景：非酒精性脂肪肝（onalcoholic fatty liver disease, NAFLD）与遗传、环境密切相关，广东省有其独特的经济文化特点，该地区NAFLD的发病情况及特点系统报告。目的：调查广东省人群NAFLD的患病率及其主要危险因素。方法：用多阶段分层随机整群抽样方法，选择广东省内6个城乡居民点，对7岁以上整体人群进行问卷调查、体、和超检查。结果：广东省3543人中NAFLD患530例15.0%，其中男性女性16.1%，P0.05）。城市人群患病率高于农村11.1%，P0.001）。按地区、年龄、性别标准化后广东省成人NAFLD的患病率为.7%。无论男女NAFLD的患病率随年龄增长而增加，6070岁患病率达峰26.9%）。多因素Logistic回归分析显示男性、城市居住、文化程度低、高血压、肥胖、腰臀比、腰围以及血甘油和血糖升高是NALFD的危险因素。结论：广东省NAFLD患病率较高，肥胖及其相关的多元代谢紊乱的关系密切。关键词脂肪肝；流行病学；患病率；危险因素 Epidemiological urvey on Prevalence of Nonalcoholic Fatty Liver Disease in a General Population of Guangdong Province ZHOU Yongjian, LI Yuyuan, NIE Yuqiang, MA Jinxiang, LU Lungen, SHI Shengli. Department of Gastroenterology and Hepatology, Guangzhou First Municipal People’s Hospital,Guangzhou (510180) Background: Nonalcoholic fatty liver disease (NAFLD) is closely related with heredity and environment. Guangdong province has its special economic cultural characteristics in China, the prevalence and characteristics of NAFLD in this area has not been reported yet. Aims: To investigate the prevalence and risk factors of NAFLD in Guangdong province. Methods: A cross-sectional survey with randomized multistage stratified cluster sampling of inhabitants over 7 years old in 6 urban and rural areas of Guangdong province was performed. Questionnaires, anthropometric measurements, biochemical tests and abdominal ultrasonography were carried out. Results: Among 3543 subjects, 530 (15.0%) were diagnosed as having NAFLD, the prevalence in male was markedly lower than that in female (13.0% vs. 16.1%, P0.05), the prevalence in urban was significantly higher than that in rural area (20.3% vs. 11.1%, P0.001). After adjustments for age, gender and residency, the standardized prevalence of NAFLD was 11.7%. The overall prevalence of NAFLD increased with age in both genders to the peak of 26.9% in 60-70 year group. Multivariate Logistic regression analysis in