藏缅群体遗传结构与研究揭示南部藏缅混合有性别差异.pdfVIP

Am. J. Hum. Genet. 74:856–865, 2004 Analyses of Genetic Structure of Tibeto-Burman Populations Reveals Sex-Biased Admixture in Southern Tibeto-Burmans 1 1 1 1 2,3 1 1 Bo Wen, Xuanhua Xie, Song Gao, Hui Li, Hong Shi, Xiufeng Song, Tingzhi Qian, 2 1 3,4 1 4 1,4 Chunjie Xiao, Jianzhong Jin, Bing Su, Daru Lu, Ranajit Chakraborty, and Li Jin 1State Key Laboratory of Genetic Engineering and Center for Anthropological Studies, School of Life Sciences, Fudan University, Shanghai; 2 Department of Biology and Human Genetics Center, Yunnan University, and 3 Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming; and 4Center for Genome Information, Department of Environmental Health, University of Cincinnati, Cincinnati An unequal contribution of male and female lineages from parental populations to admixed ones is not uncommon in the American continents, as a consequence of directional gene flow from European men into African and Hispanic Americans in the past several centuries. However, little is known about sex-biased admixture in East Asia, where substantial migrations are recorded. Tibeto-Burman (TB) populations were historically derived from ancient tribes of northwestern China and subsequently moved to the south, where they admixed with the southern natives during the past 2,600 years. They are currently extensively distributed in China and Southeast Asia. In this study, we analyze the variations of 965 Y chromosomes and 754 mtDNAs in 120 TB populations from China. By examining the hap