抗瓜氨酸化纤维蛋白原抗体检测及在类风湿关节炎中临床意义_赵义.pdfVIP

( ) # 350# JOURNAL OF PEK ING UN IVERSITY (HEALTH SC IENCES) Vol. 38 No. 4 Au . 2006 # 论著# 抗瓜氨酸化纤维蛋白原抗体的检测及其在 类风湿关节炎中的临床意义 w v 赵 义, 田 昕 , 栗占国 ( , 100044) [ ] 目的: ( A CF) ( RA) 方法: ELISA 183 RA12 1 48 108 ACF, RA 结果: ACF RA 67. 2 1% , 25. 62% , 18. 75% 2. 78% , RA 67. 2 1% , 84. 84% , 74. 55% RA A CF 3 (P 0. 00 1) RA , ACF ( r = 0. 386, P 0. 001) ( CCP) ( r = 0. 239, P 0. 05) ( AKA ) ( r = 0. 288, P 0. 05)A CF ESRX IM-RF CCP AKA , IM-RFAKA A CF结论: ACF RA , CCP AKA , ACF, ACF RA [ ] ; ; ; , [ ] R5931220. 4 [] A [] 1671-167X ( 2006) 04-0350-06 Diagnostic values of antibody to citrullinated human fibrinogen in rheumatoid arthritis w v ZHAO Y i, T IAN X in , LI Zhan- uo ( Department of Rheum atolo y and Immunolo y, Pek in Un iversity People. s H osp ital, Beijin 100044, Ch ina) ABSTRACT Objective: To study the prevalence of antibody to citrullinated human fibrino en ( ACF) in rheum atic diseases and the dia nostic values in rheumatoid arthritis. M ethods: Human fibrino en w as 2+ demi inated by the peptidylar inine demi inase ( PAD) in the presence of Ca in vitro. ACF w as detected by ELISA in 352 patients w ith rheum atic d iseases ( 183 RA, 121 SLE and 48 OA ) and 108 healthy con- trols. The sensitivity and specificity in RA w ere calcu lated and the correlations bewt een ACF and the clinical and laboratory parameters w ere analysed by SPSS statistical sofwt are. Results: Compared w ith SLE ( 25. 62% ), OA ( 18. 75% ) and healthy control ( 2. 78% ) respectively, the patientsw ith RA had a si n ificantly h i her level ofACF ( 67. 21