环己烯巴比妥-代谢酶诱导小鼠研究_计算生物学_科研数据集.pdfVIP

环己烯巴比妥-代谢酶诱导小鼠研究 (Hexobarbital-Metabolizing Enzyme Induction Study in Mice) 数据摘要： Fifty male and 50 female mice were assigned randomly to one of five treatment groups (10 mice of each sex/treatment group). In each sex, three groups of mice orally received one of three graded dosage levels of an investigational drug (10, 50, 250 mg/kg), one group orally received 0.9% sterile Saline (25 ml/kg) as a negative control, and one group received Sodium Phenobarbital (75 mg/kg) injected intraperitoneally. Sodium Phenobarbital was included in the experiment as a positive control since it is known to include hexobarbital metabolizing enzymes. Treatment was administered b.i.d., approximately four-and-one half hours apart, over a period of four consecutive days. A hexobarbital (100 mg/kg) injection was given intraperitoneally approximately 24 hours following the last dose of the assigned treatment. Each animals sleeping time following hexobarbital administration was measured as the duration of time (minutes) from the loss of the righting reflex to the time of spontaneous righting. One male mouse (50 mg/kg) died from an intubation accident on the fourth day of treatment. If drug administration induces hexobarbital-metabolizing enzymes, then the length of sleep should decrease with increase in dose of drug. 中文关键词： 环己烯巴比妥,代谢酶,诱导研究,老鼠,性别, 英文关键词： Hexobarbital,metabolizing enzyme,induction study,mice,sex, 数据格式： TEXT 数据用途： The data can be used for computational biology. 数据详细介绍： Favorite Datasets from Early (and Late) Phases of Drug Research Hexobarbital-Metabolizing Enzyme Induction Study in Mice Part 4 - Table 2 Abstract Fifty male and 50 female mice were assigned randomly to one of five treatment groups (10 mice of each sex/treatment group). In each sex, three groups of mice orally received one of three graded dosage levels of an investigational