ABC转运蛋白在SPC_A1细胞系中SP细胞多药耐药机制研究.pdfVIP

# 692# 22 7 Vol. 22 No. 7 2009 7 Journal ofM edical Postgraduates Jul. 2009 # # ABC转运蛋白在 SPC-A1细胞系中 SP细胞多药耐药机制的研究 朱言亮, 陈龙邦, 王靖华, 褚晓源, 陈一天, 张 群 (, 210002) : 目的:, , AB DNA AB SP -A1 方法: SP -A 1/ Docetaxel, SP -A 1 SP -A 1/ Docetaxel SPAB 结果: SP -A 1 SP -A 1/ Docetaxel SP, SP -A 1/ Docetaxel SP SP -A 1; P-gp( B RP) SP -A 1/ Docetaxel SP -A 1/ Docetaxel-SP , SP -A1 SP B RP; SP -A 1-SP SP -A 1/ Docetaxe-lSP; SP -A 1/ Docetaxel, SP -A 1-SP Docetaxel 结论: B RP SP -A1 SP, SP -A 1-SP, B RP SP -A 1-SP : AB ; ; ; ; : Q51 : A : 1008-8199( 2009) 07-0692-05* The mechanism of the role ofABC transporters in the mult-i drug resistance of SP cells in SPC-A 1 cell lines ZHU Yan-liang, HEN Long-bang, WANG Jing-hua, HU X iao-yuan, HEN Y -i tian, ZHANG Qun (Department of M edical Oncology, JinlingH osp ita,l Nanj ing 210002, Jiangsu, China) Abstract: O bj ective: Recent researches suggest that tumors are organized in a hierarchy of hetero- geneous cellpopulations and that the capability ofm aintaining tumor form ation/grow th specifically re- sides in a smallpopulation of cells called cancer stem cells ( S s). S s are resistant to traditional cancer chem otherapy and radiation therapy because they highly expressATP-binding cassette (AB ) drug transporters and are relatively quiescent, w ith higher DNA repair and anti-apoptosis abilities. The purpose of this study is to investigate the relationship ofAB transportersw ith the multi-drug re- * : 2008-11-03; : 2009-01-21 : (: 0801032