ACS患者血浆CRP的变化及与脂质的关系√.docVIP

急性冠状动脉综合征患者血浆C-反应 蛋白变化与脂质相关性的研究 许国根 陈雯 吴锦鸿 王弋 裘力锋 徐远胜 [摘要] 目的：研究急性冠状动脉综合征（ACS）患者急性期反应以及血浆C-反应蛋白（CRP）水平与血浆低密度脂蛋白（LDL）、一氧化氮（NO）、总胆固醇（TC）、甘油三脂（TG）的关系。方法：符合ACS诊断45例于入院后第2天凌晨空腹抽取肘静脉血5ml，应用速率散射免疫比浊法测定CRP并测定LDL、NO、 TC、TG，并设健康对照组。结果：ACS患者CRP水平显著升高，其中不稳定心绞痛（UAP）19例为59.08±5.12、非Q波性急性心肌梗塞（NQMI）11例为81.34±9.16、Q波性急性心肌梗塞（AMI）15例为119.51±8.43，与对照组7.29±1.54比较有显著差异（P＜0.01）；ACS患者CRP水平和LDL、NO、TC、TG有显著相关性（P＜0.01）。结论：调节LDL、NO、TC、TG的水平，达到降低CRP水平的目的是防治ACS的发生发展的有效措施。 [关键词] 急性冠状动脉综合征；C-反应蛋白；脂质；一氧化氮 The study of the relationship between the change of plasma C-reactive protein and lipid in patients with acute coronary syndrome Xu Guogen, Miao Qun, Chen Yin, Chen Wen, Zhang Xingwei, Wu Jinhong. The first municipal hospital of hangzhou, Hangzhou Zhejiang Province 310006 [Abstract] Objective: To investigate the acute phase response and the relationship between plasma C-reactive protein and serum low density lipoprotein (LDL), nitric oxide (NO), total cholesterol (TC), triglyceride (TG) in patients with acute coronary syndrome (ACS). Methods: 5ml blood was drown from elbow vein of 45 patients with ACS on an empty stomach in the morning of the 2nd day after hospitalization. CRP was detected by Velocity Scatter Immune turbidimetry, LDL, NO, TC, TG were detected, healthy objects were regarded as control group. Results: Plasma CRP level increased significantly in patients with ACS, and CRP level was significantly different between 19 patients with unstable angina pectoris (UAP, 59.08?5.12), 11 patients with non-Q wave myocardial infarction (NQMI, 81.34?9.16), 15 patients with acute Q wave myocardial infarction (AMI,119.51?8.43) and control group (7.29?1.54 ) (p0.01). CRP level in patients with ACS was significantly correlated with LDL, NO, TC, TG. Conclusions: The regulating of the level of LDL、NO、TC、TG and lowing of the level in CRP was effective measure to prevent occurrence and development of ACS. [Key words] acute coronary syndrome; C-creative protein; lipid; nitric oxide 急性冠状动脉综合征（AC