间充质干细胞免疫调控功能研究新进展.docVIP

摘要】 间充质干细胞（mesenchymal stem cells, MSC）是具有自我更新和多向分化能力的成体干细胞的一种。近年来的相关研究表明， MSC具有低免疫原性，它可以通过抑制淋巴细胞的增殖、抑制抗原呈递细胞分化成熟及功能发挥、抑制CTL形成、增加调节性T细胞比例等多种途径发挥免疫调节作用。体内实验证明，MSC输注能够延长狒狒异体皮肤移植的存活时间，可减轻小鼠实验性自体免疫性脑脊髓膜炎。在临床上，MSC应用于异基因造血干细胞移植后移植物抗宿主病的预防和治疗效果显著。本文对MSC的免疫学特性及其在体内外试验中发挥的免疫调控功能的研究进展进行了综述。 【关键词】 移植物抗宿主病 Recent Advance in Research on Immunomodulatory Function of Mesenchymal Stem Cells ——Review LI Hong, GUO ZiKuan1, MAO Ning Department of Cell Biology, Institute of Basic Medical Sciences Academy of Military Medical Sciences, Beijing 100850, China; 1Department of Experimental Hematology, Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China Abstract Mesenchymal stem cells (MSCs) are a kind of adult stem cells which have the capability to differentiate into multiple cell types as well as selfrenew continuously. Recent studies demonstrate that MSCs are low immunogenic and able to exert immunomodulatory function by various approaches, such as suppression of the lymphocyte proliferation, reduction of the dentritic cell generation, maturation and function, downregulation of the CTL formation and enhacement of regulatory Tcell proportion. In vivo experiments show that MSC infusion can prolong the survival time of alloskin graft in baboon and ameliorate experimental autoimmune encephalomyelitis in mice. Successful reports have been documented about clinical application of MSC in the management of graftversushost disease. In this review, the immunological characteristics and the immunomodulation functions in vitro and in vivo of MSC were summarized. Key words mesenchymal stem cells; immunomodulation; graftversushost disease J Exp Hematol 2007; 15(5):1117-1120 间充质干细胞（mesenchymal stem cells, MSCs）是具有自我更新和多向分化为骨、脂肪、软骨等中胚层细胞的一种成体干细胞。现在人们已可以从多种物种的成体的多种组织中分离出MSC，体外和体内实验均证明了MSC及其分化细胞可给予造血细胞结构和功能上的支持，具有造血调节作用。MSC成为了组织工程和骨髓移植细胞治疗的研究热点。近年来，MSC的免疫调节功能逐渐受到人们的重视。 MSC表面分子免疫特性与异基因识别 MSC细胞表面只表达