晚期结直肠癌术中使用铜绿假单胞菌注射液的长期疗效探讨.pdfVIP

526 中国肿瘤临床2014年第41卷第8期 Chin J Clin Oncol 2014,Vol.41,No.8 晚期结直肠癌术中使用铜绿假单胞菌注射液的长 期疗效探讨 林 涛 宋 纯 王 辉 探讨晚期结直肠癌术中腹腔局部注射铜绿假单胞菌注射液的长期疗效。 收集自2006年9月至2008年3 摘要 目的： 方法： 月间晚期结直肠癌患者共83例入组，其中包括治疗组30例（姑息性手术切除加术中局部注射铜绿假单胞菌注射液10mL），对照 组53例（仅姑息切除肿瘤），治疗组和对照组术后继续应用化疗和/或放疗。 79例患者最终完成随访，随访率达95.2%。两 结果： 组之间5年总生存时间无差异性（P=0.403），但是对照组5年的中位生存期仅为（13.9±2.14）个月，而治疗组为（17.2±2.12）个月。 晚期结直肠癌术中腹腔局部注射铜绿假单胞菌注射液，可能在短期内具有一定的生存优势，但是长期疗效还有待考证。 结论： 关键词 晚期结直肠癌 铜绿假单胞菌注射液 术中用药 五年生存率 中位生存期 doi:10.3969/j.issn.1000-8179 Long-term effect of pseudomonas aeruginosa preparation on advanced colorectal cancer during surgery Tao LIN, Chun SONG, Hui WANG Correspondence to: Chun SONG; E-mail: chunsong163@163.com Department of Gastro-intestinal Surgery, Liaoning Provincial Tumor Hospital, Shenyang 110042, China Abstract Objective: This study aimed to observe the long-term effect of Pseudomonas aeruginosa preparation used in peritoneal injection of advanced colorectal cancer patients during surgery. Methods: A total of 83 colorectal cancer patients who received surgery between September 2006 and March 2008 were enrolled in this study. The patients were divided into two groups. Palliative resection and a 10 ml P. aeruginosa peritoneal injection were performed in 30 of 83 patients in the treatment group. Simple palliative resection was conducted in the other 53 patients, which comprised the control group. Both groups were then treated by regular chemotherapy and radiotherapy. Results: The follow-up visit was completed in 79 of 83 patients, with a high follow-up rate of 95.2%. No significant di