家蚕作为模式生物在现代生物学中应用.pdfVIP

家蚕作为模式生物在现代生物学中的应用 朱晓苏, 宋艳, 徐世清∗ （现代丝绸国家工程实验室，苏州大学医学部应用生物学系，江苏苏州 215123 ） 摘 要 家蚕作为鳞翅目昆虫的典型代表和理想的生物学模型对动物科学的发展起到了巨大 的推动作用，其特殊突变已经成为现代遗传工程研究的优良材料。随着家蚕全基因组框架图和 精细图制作的完成，家蚕将成为后基因组时代生命科学研究领域较为理想的模式生物。本文综 述了家蚕对现代遗传学的贡献，分析了家蚕作为模式生物在发育生物学、生物反应器和基因组 分子平台建设等研究领域的现状，论述了家蚕作为模式生物的在现代生物学领域的应用前景。 关键词 家蚕；模式生物; 发育; 遗传 Application of Bombyx mori as the Model Organism in Modern Biology ZHU Xiao-su, SONG yan, XU Shi-qing (National Engineering Laboratory of Modern Silk, Department of Applied Biology, Medical College, Soochow University, Suzhou, Jiangsu 215153, Chin ） Abstract Silkworm, i.e. Bombyx mori, as the typical representative of Lepidopteran insect and the ideal biological model, has played a significant role in promoting the development of animal science, which specific mutation has already been the optimum material for the research on modern genetic engineering. With the accomplishment of the draft of the silkworm genome and the fine map, silkworm will further become a comparatively ideal model organism in the field of research on life sciences in post-genome era. This text summarized the silkworm’s contributions to the modern genetics; again, analyzed the status quo of silkworm as the model organism in researching realms of developmental biology, bioreactor, and the construction of molecular platform of genome and so forth; and finally, discussed the application of silkworm being the model organism in the field of Modern Biology. Keywords Bombyx mori ; Model of organism; Developmental biology; Genetics [1] 20 世纪初, 家蚕（Bombyx mori ，L. ）就成为著名的模式生物 。2002 年国际无脊椎动物协会 将家蚕确定为鳞翅目模式昆虫。作为鳞翅目昆虫的典型代表和理想的生物学模型，家蚕对动物科 学的发展起到了巨大的推动作用。