镰孢菌属真菌次生代谢产物研究进展.pdf

植物生理学报 Plant Physiology Journal 2013, 49 (3): 201~2 16 201 特约综述 Invited Review 镰孢菌属真菌次生代谢产物的研究进展 1,2 1,* 张晓伟 , 张栋 1 , 200032; 2 , 中国科学院上海生命科学研究院植物生理生态研究所植物分子遗传国家重点实验室 上海 中国科学院大学 北京 100049 : , 摘要 镰孢菌属包括禾谷镰孢、串珠镰孢和尖孢镰孢等主要的植物病原真菌 能够产生多种次生代谢产物。依据结构和合 , ( ) ( ) 成途径 次生代谢产物可以分为聚酮类黄色镰刀菌素、伏马毒素和玉米赤霉烯酮等 、萜类单端孢霉烯和类胡萝卜素等 ( ) , 和非核糖体多肽类铁载体等三种主要的类型。其中 萜类中的单端孢霉烯和聚酮类的伏马毒素对人畜的健康威胁最大。 本文对这些次生代谢产物的种类、作用、合成及其调节机制进行简单的概述。 : ; ; ; ; 关键词 镰孢菌属真菌 次生代谢产物 聚酮类 萜类 非核糖体多肽类 Recent Advances of Secondary Metabolites in Genus Fusarium ZHANG Xiao-Wei1,2, ZHANG Dong1,* 1National Key Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Science, Shanghai 200032, China; 2 University of Chinese Academy of Sciences, Beijing 100049, China Abstract: The genus Fusarium includes a number of important plant pathogens such as Fusarium graminear- um, Fusarium moniliforme and Fusarium oxysporum, which are capable of producing many secondary metabo- lites. According to structure and biosynthetic pathway, the secondary metabolites can be grouped into three classes: polyketides including aurofusarin, fumonisin and zearalenone; terpenes including trichothecene and carotenoid; nonribosomal peptides including siderophore. Among these, trichothecene and fumonisin are myco- toxins that affect human, animal health. Here we review current understanding of the classification, function, biosynthesis and regulation of the secondary metabolites produced by Fusarium fungi. Key words: Fusarium ; secon