重症败血症患者炎性介质水平对预后的影响.pdfVIP

2001 11 13 11 671 1 2 1 3 3 3 赵擎宇, 张春玲 , 黄子通,M A Weigand H J Bardenheuer E Martin, , (1. , 510120;2.; 3.) : ::, 28 , :26 , 14 (53. 8 ) , 1 (74. 0 ) 4(SIRS) 1(sICAM 1) , 2 : sICAM 1 : ;; 1; : 257; 631.3: : 1003 0603( 2001) 11 0671 04 Q R A Significance of inflammatory mediators in outcome prediction of patients with severe sepsis ZH A O Qing 1 2 1 3 3 3 1 y u ,ZH A N G Chun ling ,H UA N G Zi tong ,M A Weig and ,H J Bard enheuer ,E M artin . De artment of Emergency , S un Yat sen M emorial H os ital, S un Yat sen University of M edical S ciences, Guangz hou Guang dong 510120 Abstract: Obj ective:To investigate prognostic markers from inflammatory mediators for sepsis outcome. Methods:Twenty six ICU patients with severe sepsis were included to observe for a 28 day interval. : 26 ( 53.8 ), (74.0 ) . Results Fourteen of the patients died mortality rate most of them in the first week Cir- culating soluble intercellular adhesion molecule 1(sICAM 1) wasfound to bean outstanding factor in predi- cating mortality and organ failurewhile some other adhesion molecules and cytokines not In addition scores of. , systemic inflammatory response syndrome parameters demonstrated great difference between survivors and non survivors Conclusions sICAM. : 1levels enableearly prediction of organ dysfunction and mortality in pa- tients with severe sepsis. Key words sepsis inflammatory mediators soluble intercellular adhesion molecule: ; ; 1; mortality prediction