A型肉毒毒素膀胱三角区黏膜下注射治疗氯胺酮相关性膀胱炎的临床研究_杨青山.pdf

临床研究 A 型肉毒毒素膀胱三角区黏膜下注射治疗氯胺酮相关性膀胱炎的临床研究 杨青山, 张晓忠,宋明哲,贺 飞,陈 海,邬绍文 (深圳中山泌尿外科医院,广东深圳 518045） Clinical observation of treatment for Ketamine associated cystitis with suburothelial injection of botulinum A toxin YANG Qing-shan, ZHANG Xiao-zhong, SONG Min-zhe, HE fei, CHEN Hai, WU Shao-wen (Department of Urology, Shenzhen zhongshan Urological Hospital, Shenzhen 518045, China) ABSTRACT: Objective To explore the clinical effects of suburothelial injection of botulinum a toxin (BTX-A) combined with bladder installation of alkaline lidocaine and hydraulic expansion in the treatment of Ketamine associated cystitis. Methods A total of 33 cases of Ketamine associated cystitis were divided into two groups: group A (n = 15) and group B (n = 18). Group A received bladder installation of alkaline lidocaine and hydraulic expansion , group B underwent the same treatment with group A, plus suburothelial injection of BTX-A. The changes of symptoms 1 week, 1 month and 3 months after treatment were evaluated, including daily emiction frequency, maximum bladder capacity and O ’Leary-Sant interstitial cystitis symptom score of ICSI and ICPI, and all adverse reactions were recorded. Results There were significant differences in daily emiction frequency, maximum bladder capacity and O ’Leary-Sant interstitial cystitis symptom score of ICSI and ICPI between group A and B. No patients had serious adverse reaction. Conclusion BTX-A combined with alkalinized lidocaine hydrostatic is a safe and effective treatment for Ketamine associated cystitis and serious complications. KEY WORDS: botulinum toxin A; lidocaine; Ketamine; cystitis 摘要：目的 探讨A 型肉毒毒素 （BTX-A ）联合碱化利多卡因膀胱灌注+水压扩张治疗氯胺酮相关性膀胱炎的疗效。 方法 将33 例氯胺酮相关性膀胱炎患者按治疗方式分为2 组：A 组15 例，采用碱化利多卡因膀胱灌注+水压扩张；B 组 18 例，在同A 组治疗的基础上，加用膀胱三角区黏膜下注射BTX-A 治疗。评估患者治疗前及治疗后1 周、1