促性腺激素释放激素激动剂治疗左炔诺孕酮缓释系统所致阴道不规则出血的效果.pdfVIP

中国医药导报 2014年7月第 11卷第21期 窑论 著 窑 促性腺激素释放激素激动剂 治疗左炔诺孕酮缓释系统所致阴道不规则出血的效果 李晓红 杜 蓉 丁 岩银 新疆医科大学第一附属医院妇科袁新疆乌鲁木齐 830054 [摘要] 目的对促性腺激素释放激素激动剂渊GnRH-a冤治疗左炔诺孕酮缓释系统渊LNG-IUS冤所引起的阴道不规则 出血的效果进行评价遥 方法选择2012年 1~7月于新疆医科大学第一附属医院妇科门诊就诊的40例子宫内膜 异位症患者为研究对象袁 根据其经济情况及自愿原则分成两组袁 每组20例遥 实验组注射GnRH-a 3次后放置 LNG-IUS袁对照组直接放置LNG-IUS遥观察两组治疗前袁放环后6尧12个月的痛经评分尧月经前半周期静脉血的雌 二醇渊E 冤水平尧月经间期阴道淋漓出血时间尧月经间期阴道淋漓出血量评分等指标遥 结果 与治疗前比较袁实验 2 组和对照组在放环后各时间点痛经评分均明显下降袁月经间期阴道淋漓出血时间及出血量均明显增加袁差异均 有统计学意义渊P约0.05冤袁月经前半周期静脉血的E 水平均无显著变化袁差异无统计学意义渊P0.05冤遥 放环6尧2 12个月后袁实验组的月经间期阴道淋漓出血时间[1.00渊0.00袁1.00冤尧0.00渊0.00袁0.75冤d]尧月经间期阴道淋漓出血量 评分[1.00渊0.00袁2.00冤尧0.00渊0.00袁0.75冤分]均低于对照组[3.00渊0.00袁4.00冤尧1.00渊0.00袁2.00冤d曰8.50渊0.00袁14.75冤尧1.00 渊0.00袁3.75冤分]袁差异均有统计学意义渊P 约0.05冤曰实验组痛经评分及静脉血E 水平与对照组比较袁差异均无统计2 学意义渊P0.05冤遥 结论 GnRH-a可有效改善LNG-IUS所致的月经间期阴道淋漓出血遥 [关键词] 不规则阴道出血曰左炔诺孕酮曰药物缓释系统曰促性腺激素释放激素激动剂 [中图分类号] R711.7 [文献标识码]A [文章编号] 1673-7210渊2014冤07渊c冤-0017-04 Efficacy of GnRH-a in reducing intermenstrual vaginal bleeding in users oftheLevonorgestrelintrauterine system LIXiaohong DURong DING Yan银 Department of Gyneacology, the First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region 830054,China [Abstract] Objective To explore the efficacy of GnRH-a in reducing intermenstrual vaginal bleeding in users of the Levonorgestrel intrauterine system (LNG-IUS)援 Methods 40 cases of endometriosis from January to July 2012 in the First Affiliated Hospital of Xinjiang Medical University were selected as study objects, and they were divided into two groups according to patientswill, treatment group and control group, with 20 cases in each group援The treatment group were inserted LNG-IUS following 3 courses of treatment by GnRH-a and the