急性白血病患者合并感染病原菌分布及耐药性分析.pdfVIP

安摇 徽摇 医摇 学 第34卷第12期 1766 Anhui Medical Journal摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 2013年12月 急性白血病患者合并感染病原菌分布及耐药性分析 倪摇 婧摇 金广霞摇 夏海龙摇 夏瑞祥 摇 摇 [摘摇 要]摇 目的摇 分析急性白血病患者合并感染的病原菌分布及耐药性,为临床防治感染提供依据。 方法摇 菌株分离与鉴定 按照《全国临床检验操作规程》进行细菌分离培养,药敏试验按照CLSI规定的判断标准进行判定。 结果摇 215株病原菌中,革兰阴 性杆菌占57.67%,革兰阳性球菌占28.37%,真菌占13.95%;大肠埃希菌和肺炎克雷伯菌对碳青霉烯类抗菌药物敏感,其次对阿米 卡星和头孢他啶敏感,铜绿假单胞菌对哌拉西林/ 他唑巴坦耐药率最低,为12.5%,金黄色葡萄球菌对糖肽类抗菌药物敏感,而对青 霉素类药物耐药。 结论摇 急性白血病患者是感染的易感人群,以革兰阴性杆菌感染为主,对常用抗菌药物耐药性增加,积极防治感 染,有助于降低感染相关死亡率。 [关键词]摇 急性白血病;感染;病原菌;耐药性 doi:10.3969/ j.issn.1000-0399.2013.12.011 Analysis of distribution and antimicrobial resistance of pathogens isolated from patients with acute leukemia NiJing,Jin Guangxia,XiaHailong,et al Department of Hematology,the FirstAffiliated Hospital of AnhuiMedical University,Hefei230032,China [Abstract]摇 Objective摇 To analyse the clinic distribution and antimicrobial resistance of pathogens isolated from patients with acute leukemia and to provide evidencefor clinical prevention and control infection.Methods摇 Pathogenic strainswere cultured and identified ac鄄 cordingtotheNationalGuidetoClinicalLaboratoryProcedures. DrugsusceptibilitytestwasidentifiedbytheCLSIstandard.Results摇 Among 215 strains of pathogens,gram-negativebacilli,gram-positivebacilli andfungi accountedfor57.67%,28.37% and 13.95% respective鄄 ly. The susceptibility test results indicated Escherichia coli and Klebsiell were susceptible to carbapenems antibiotics,secondly to amikacin and ceftazidime. Theresistancerateofpseudomonasaeruginosatopiperacillin/ tazobactamwas12.50%. Staphylococcusaureuswassuscepti鄄 摇 摇 作者单位:230032摇 合肥摇 安徽医科大学第一附属医院血液科 件,且其术后护理与传统换药治疗相比,患者痛苦小, [5]摇 Morykw MJ,Argenta LC,Shelton-Brown EI,et al. Vacu鄄 也减小了医护人员的工作量,值得大力推广。 um-assisted closure:a new method for WOulld control and