Association between Autoantibodies against Angiotension Ⅱ Type 1 Receptor and Pre-Eclampsia (Review).pdfVIP

Advances in Clinical Medicine 临床医学进展, 2013, 3, 1-4 /10.12677/acm.2013.31001 Published Online March 2013 (/journal/acm.html) Association between Autoantibodies against Angiotension Ⅱ * Type 1 Receptor and Pre-Eclampsia (Review) 1 2 1# Guiling Ma , Yanfang Li , Lin Zhang 1Heart Centre, Capital Medical University, Chao-Yang Hospital, Beijing 2Gynaecology and Obstetrics Department, Capital Medical University, Chao-Yang Hospital, Beijing Email: #linzhangpeking@ Received: Dec. 28th th th , 2012; revised: Jan. 10 , 2013; accepted: Jan. 24 , 2013 Abstract: Pre-eclampsia is a serious hypertensive disorder of pregnancy that affects 3% - 5% of pregnancies, and re- mains the leading cause of maternal and neonatal mortalities and morbidities in the world. It is a multisystemic disease with the common features of hypertension and proteinuria. In serious cases, termination of pregnancy is the only avail- able option to prevent further deterioration of the fetus and mother. At present, the factors triggering, and the underlying mechanisms, responsible for the pathogenesis of pre-eclampsia remain unknown. Recently, numerous studies have shown that pre-eclamptic women possess autoantibody against angiotensin Ⅱ type 1 receptor, which bound to and activated the receptor provoking biological responses relevant to the pathogenesis of pre-eclampsia. The current paper is to review the most recent development. Keywords: Pre-Eclampsia; Angiotension Ⅱ Type 1 Receptor; Autoantibody 血管紧张素Ⅱ1 型受体自身抗体与子痫前期* 1 2 1# 马桂伶 ，李艳芳 ，张 麟 1 首都医科大学附属北京朝阳医院心脏中心，北京 2 首都医科大学附属北京朝阳医院妇产科，北京 Email: #linzhangpeking@ 收稿日期：2012 年 12 月 28 日；修回日期：2013 年 1 月 10 日；录用日期：2013 年 1 月 24 日 摘 要：子痫前期以高血压、蛋白尿为特征，并伴有全身多脏器的损害。其发病率为 3%~5%，是母婴发病率及 死亡率较高的主要原因。重症患者只有及时终止妊娠才可阻止孕