浅析中药注射剂不良反应发生原因及防治措施.pdfVIP

浅析中药注射剂不良反应发生原因及防治措施 高素珍’，张志刚(山西阳煤集团总医院药学部，阳泉市045000) 中圈分类号 R288；R963．3文芒标识码 C 文章编号 1001-0408(2008)18-1439-02 摘要 目的：促进临床合理用药。方法：通过查阅相关文献资料，对中药注射荆不良反应的发生原因进行分析。结果：导致中药注 射荆不良反应发生的原因包括：中草药所含的有效成分；制备成中药注射剂后其稳定性差，制剂工艺不尽合理；在临床使用时不对 证，配伍不当，剂量不当，操作不当及患者的个体差异。结论：临床应用中药注射剂时，应加强用药监护，严格按照药品适应证范围使 用，使用前详细了解患者过敏史，认真检查注射剂是否合格，特别注意配伍应用，这样可大大减少或避免不良反应的发生。 关键词 中药注射剂；不良反应；原因；预防 ADRInducedChineseMedicine andCountermeasures by Injections：Causes GAO Coal General Su．zhen，ZHANGZhi—gang(Dept．of Pharmacy，YangquanGroup 045000，China) use ABSTRACT rational inthe the literature 0BJECTIvE：Topromote drug clinic．砸THODs：Byreviewingpertinent and of Chinese bothathomeabroad。thecausesADRsinduced medicine were reasons by injectionsanalyzed．RESULTS：the for Chinese as in accountableADRsinduced medicineinjectionswerefollows：theactive theChineseherbal by ingredients of andtheunreasonable tofollowindicationsinthe medicine；poorstabilitypreparation preparationprocess；failing treatment， administrationandindividualdifferences．CONCLUSION：Itis to drugincompatibility，improperdosage，improper necessary in clinical ofChinesemedicine strengthenmonitoringapplication injections．Onlythroughstrictlyfollowing into before surethe ofthe is attentionto drug injection ing allergyhistory use，makingquality qualified，payingspecial drug cantheADRsbe reducedoravoided． compatibility gre