尿脱落细胞6号染色体长臂的微卫星改变诊断膀胱肿瘤_医学论文.docVIP

尿脱落细胞6号染色体长臂的微卫星改变诊断膀胱肿瘤_医学论文 尿脱落细胞6号染色体长臂的微卫星改变诊断膀胱肿瘤_医学论文 作者：成凡，楚雍烈，贺大林，杨林，陈萍，杨娥 【关键词】 膀胱肿瘤 　　【Abstract】AIM： To investigate the microsatellite alteration (MA) at chromosome 6q in the early diagnosis of bladder tumor and to study whether the loss of heterozygosity (LOH) at 6q is related to the development of bladder tumor. METHODS： D6S404 and D6434 microsatellite markers near 6q21 were tested by PCRSSLPstain method in both the urine sediment DNA and tumor DNA from 31 cases of bladder tumor. RESULTS： Among the 31 cases of bladder tumor, 64.5% of the tumor tissue DNA and 581% of the urine sed