性激素受体与甲状腺疾病的相关性_医学论文.docVIP

性激素受体与甲状腺疾病的相关性_医学论文 性激素受体与甲状腺疾病的相关性_医学论文 作者：林旭明　宁莫凡　晋援朝 【关键词】 受体 　　关键词: 受体，雌激素受体，孕酮甲状腺肿瘤酶联亲合组化法 　　摘 要:目的 探讨甲状腺肿瘤与雌、孕激素受体（ER，PR）的相关性. 方法 采用酶联亲合组化法对手术切除的甲状腺标本100例进行ER及PR检测，其中甲状腺癌35例，甲状腺腺瘤19例，结节性甲状腺肿22例，正常甲状腺组织24例. 结果 ER及PR的阳性率分别为:甲状腺癌49%和71%甲状腺腺瘤37%和42%结节性甲状腺肿18%和22%正常甲状腺组织4%和8%.甲状腺癌和腺瘤组织中ER及PR的阳性率，均明显高于甲状腺正常组织（0.01～0.05）.年龄lt40岁组的甲状腺癌ER阳性率，明显高于gt40岁组（0.05）.女性甲状腺癌PR的阳性率明显高于男性（0.05）. 结论 甲状腺良、恶性病变及正常组织中均可检测到ER及PR，以甲状腺癌组织中含量最高，甲状腺腺瘤次之.女性激素很可能是诱发甲状腺癌的重要因素，分化型甲状腺癌可能是女性激素依赖性肿瘤，ER及PR的检验有助于甲状腺癌的早期诊断和鉴别诊断. 　　Keywords:receptors，estrogenreceptors，progesteronethyroid neoplasmsenzyme-linked affinity histo-chemical method 　　Abstract:AIM To probe the correlation between the thy-roid tumor and the receptors of estrogen and progesterone.METHODS Estrogen receptor（ER）and progesterone re-ceptor（PR）of the thyroid tissues were determined by using enzyme-linked affinity histochemical technique in100patients with different thyroid diseases.Among them，35patients with thyroid cancer，19thyroidoma，22tuberous thyrocele and24with normal thyroid tissue.RESULTS Positive rates of ER and PR in cancer，adenoma，thyrocele and normal thy-roid tissue were49%and71%，37%and42%，18%and22%，4%and8%，respectively.The positive rates of both ER and PR in thyroid cancer and thyroidoma were higher than that in normal thyroid tissue（0.01～0.05）.The positive rate of ER in patients aged less than40years was higher than that in patients aged more than40years（0.05）.No significant difference of the positive rate of PR was found in these two groups.Whereas，female patients had higher PR positive rate than male patients（0.05）.CON┐CLUSION Neoplastic and noneoplastic thyroid tissues con-tain ER and PR.The carcinoma tissues have the highest posi-tive rates of ER and PR，then comes thyroidoma.The female hormone may play an important role in the development of thyroid cancer.The differentiated thyroid cancer may be the female hormone-dependent type.The examination of ER and PR has significance in the early diagnosis and diffe