慢性肝病患者自评量表的应用评价研究_医学论文.docVIP

慢性肝病患者自评量表的应用评价研究_医学论文 慢性肝病患者自评量表的应用评价研究_医学论文 作者：刘慧敏,刘绍能,刘震,陶夏平 【摘要】 目的 评价慢性肝病患者自评量表的信度、效度及反应度。方法 以慢性乙型肝炎、慢性丙型肝炎、酒精性肝炎、脂肪性肝炎、肝硬化代偿期为研究对象,应用我们以往研究编制的慢性肝病患者自评量表进行测评。共纳入患者104例,与51例正常人对照,进行信度、效度、反应度分析,并对慢性肝病患者与正常人、慢性乙肝患者与其他肝病患者进行对比分析。结果 该量表总体克朗巴赫α系数为0.915,总体Guttman折半系数0.703该量表KMO统计量为0.783,Bartlett球形检验卡方值1801.149(0.001),主成分因子分析方法提取特征根值gt1的8个公因子,累计贡献率为69.636%以t检验方法分别分析慢性肝病患者与正常人、慢性乙肝患者与其他肝病患者量表总分,P值分别为0.000、0.413。结论 该量表有较好的信度、效度及反应度,可作为慢性肝病患者临床疗效的评价工具。 【关键词】 慢性肝病自评量表信度效度反应度 　　Abstract：Objective To explore the reliability, validity and reaction degree of patient reported outcome instrument for chronic hepatitis diseases. Methods One hundred and four cases with chronic B hepatitis, chronic C hepatitis, alcoholic liver disease, steatohepatitis and decompensated cirrhosis were included and tested by patient reported outcome instrument for chronic hepatitis diseases and compared with 51 normal people. The reliability, validity and reaction degree were analyzed. The chronic hepatitis patient and normal people, chronic B hepatitis and other patients with liver disease were compared. Result The total Cronbach’s Alpha of the instrument was 0.915, the total split-half reliability was 0.703, the KMO value was 0.783, Bartlett test value was 1 801.149 (0.001), factor analysis resulted in 8 factors with eigenvalue gt 1, which contributed to 69.636%. The chronic hepatitis patients and normal people, chronic B Hepatitis patients and others were analyzed respectively by T test, P value were 0.000 and 0.413 respectively. Conclusion The instrument has a good internal reliability, validity and reaction degree, which can be applied for the therapeutic evaluation of chronic hepertatis diseases. 　　Key words：chronic hepatitis diseasespatients reported outcomescalereliabilityvalidityreaction degree 　　我们采用量表研制的相关策略和方法,编制了符合我国人文特点及语言习惯的慢性肝病患者报告结局(Patient Reported Outcomes,PRO)的初步量表[1]。经过专家的反复论证、修改与完善,形成了慢性肝病患者自评量表,为评价该量表的可靠性,我们对该量表进行了信度、效度及反应度检验,现报道如下。 　　1 病例选择 　　1.1 诊断标准 　　1.1.1 慢性乙型肝炎 采用2000年9月中