漆树叶引起接触性皮炎1例报告_药学论文.docVIP

漆树叶引起接触性皮炎1例报告_药学论文 漆树叶引起接触性皮炎1例报告_药学论文 【摘要】 目的 研究脂微球携载前列腺素E1（Lipo）对闭塞性动脉硬化症(ASO)患者血管内皮功能的影响。方法 将65 例ASO患者随机分为两组，Lipo治疗组38例在常规治疗基础上加用Lipo（110μg/d），静脉滴注，共2个疗程，常规治疗组27例仅接受常规治疗。观察治疗前和治疗 2 个月后血清内皮素( ET)、一氧化氮(NO)、血管性假血友病因子(Von Willebrand factor,vWF)、6酮前列腺素F1α (6F1α)水平的变化。结果 ①常规治疗组治疗后ET显著降低(0.01)，NO显著升高(0.01)，vWF有下降趋势，6有升高趋势，但均未达统计学意义；②Lipo治疗组治疗后ET、vWF水平显著降低(0.01)，NO、6水平显著升高(0.01)；③治疗后Lipo治疗组NO、6水平高于常规治疗组(0.01)，ET、vWF水平低于常规治疗组(0.01)。结论 Lipo可能通过降低血清 ET、vWF,提高 NO、6水平等途径改善闭塞性动脉硬化症患者血管内皮功能,提高临床疗效。 【关键词】 脂微球携载前列腺素E1；闭塞性动脉硬化症；血管内皮功能 ABSTRACT： Objective To evaluate the effect of liposomal prostaglandin E1（Lipo） on vascular endothelial function in patients with arterilsclerotic obliterance (ASO).Methods Sixtyatients were randomly divided into two group, the 38 patients in therapy group treated by conventional therapy plus LipoPGE1 and the 27 patients in control group treated by conventional therapy alone. The changes of endothelin (ET),nitric oxide (NO),Von Willebrand factor(vWF),and 6ketoprostaglandin F1 alpha(6KPGF1α)levels in blood from before treatment to two months after treatment were observed.Results In conventional therapy group,the level of blood ET was obviously decreased(0.01),and the level of NO was increased(0.01).The levels of blood vWF and 6KPGF1α were also changed,but there werent statistical meaning.②In LipoPGE1 therapy group，the levels of vWF , ET were lowered(0.01)，and the levels of NO and 6t compared with the conventional therapy group,the level of NO and 6KPGF1αwere obvious higher(0.01),and the level of vWF , ET were lower(0.01).Conclusion LipoPGE1 may protect vascular endothelium,improve clinical therapeutic effect by decreasing the levels of blood ET , vWF,and increasing the levels of NO and 6KPGF1α. KEY WORDS：Liposomal prostaglandin E1；Arterilsclerotic Obliterance；Vascular；Endothelial function 闭塞性动脉硬化症(ASO)是全身性动脉粥样硬化在肢体局部的表现。研究表明，血管内皮功能障碍在动脉粥样硬化形成早期即存在，是促进动脉粥样硬化发生和发展的重要始动因素[1]。保护或改善血管内皮功能对ASO的治疗是至关重要的。本研究拟通过观察闭塞性动脉硬化症患者血清内皮素(ET)、血管性假血友病因子(