环氧化酶2及表皮生长因子受体在非小细胞肺癌组织中的表达及临床意义_医学论文.docVIP

环氧化酶2及表皮生长因子受体在非小细胞肺癌组织中的表达及临床意义_医学论文 环氧化酶2及表皮生长因子受体在非小细胞肺癌组织中的表达及临床意义_医学论文 【摘要】 目的 探讨环氧化酶2(COX2)与表皮生长因子受体(EGFR)在非小细胞肺癌(NSCLC)组织中的表达及与肺癌发生发展的关系。方法 采用免疫组化(SP)法检测56例NSCLC和20例正常肺组织中COX2与EGFR的表达。结果 56例NSCLC组织中，COX2与EGFR表达阳性率分别为64.2%和67.8%，显著高于正常肺组织(0.01)，COX2与EGFR表达与临床分期、病理分级、组织学分型和淋巴结转移密切相关(0.05)，肿瘤分期愈晚，细胞分化越差，淋巴结转移越高，COX2与EGFR表达阳性率越高，腺癌中COX2表达明显高于鳞癌，鳞癌中EGFR表达高于腺癌(0.05)。结论 COX2与EGFR在NSCLC中异常表达说明其在肺癌发生发展中有重要作用，可作为判断NSCLC的生物学行为及估计预后的指标。 【关键词】 环氧化酶；表皮生长因子受体；非小细胞肺癌 　　Expressions of cyclooxygenase2 and epidermal growth　factor receptor in nonsmall cell lung cancer 　　ABSTRACT: Objective To study the expressions of cyclooxygenase2 (COX2) and epidermal growth factor receptor (EGFR) in tumor tissues and explore the effect of COX2 and EGFR in NSCLC development. Methods The expression of COX2 and EGFR was detected by immunohistochemical technique in 56 cases of nonsmall cell lung cancer (NSCLC) and in 20 cases of normal lung tissues. Results The expression of COX2 and EGFR in NSCLC was significantly higher than that in normal lung tissues (0.01), the positive expression rate of COX2 and EGFR being 64.2% and 67.8%, respectively. The expression of COX2 and EGFR in NSCLC was associated with clinical stage, histologic grade, tumor pathological type and lymponode metastasis (0.05). The expression of COX2 and EGFR in stage III and stage IV of NSCLC was significantly higher than that in stage I and stage II of NSCLC. The expression of COX2 and EGFR in the poorlydifferentiated NSCLC was significantly higher than that in the welldifferentiated NSCLC, and lymponode metastasis in NSCLC was higher than nonlymponode metastasis(0.05). The expression of COX2 in adenocarcinoma cell was obviously higher than that in squmaous cell carcinoma the expression of EGFR in squmaous cell carcinoma was higher than that in adenocarcinoma cell (0.05). The positive correlation was found between COX2 and EGFR. Conclusion The experiment suggests that COX2 and EGFR play roles in oncog