磁化支架防治犬PTCA术后冠状动脉再狭窄_医学论文.docVIP

磁化支架防治犬PTCA术后冠状动脉再狭窄_医学论文 磁化支架防治犬PTCA术后冠状动脉再狭窄_医学论文 作者：吕安林　贾国良　郭文怡　杨省利　王小燕　胡涛 【关键词】 冠状动脉疾病 关键词: 冠状动脉疾病血管成形术，经腔，经皮冠状动脉磁化支架冠状血管/损伤 摘 要:目的 探讨磁化支架对（PTCA，Percutaneous trans-luminal coronary angioplasty）术后冠状动脉再狭窄的防治作用. 方法 20只健康杂种犬，超大球囊反复扩张损伤靶血管（前降支或旋支中段）制备PTCA术后冠状动脉狭窄模型（大于50%）后随机分成对照组和实验组各10只，对照组靶血管置入普通Palmaz支架，实验组靶血管置入磁化Palmaz支架.手术前、后不用抗血小板药和抗凝药，术后6mo冠状动脉造影并处死犬，切取靶血管3cm进行组织病理学检查. 结果 冠状动脉造影示冠状动脉再狭窄率对照组30%，实验组0组织病理学检查靶血管平均内膜厚度［对照组（2.98±0.56）mm，实验组（1.13±0.41）mm］有显著差异，0.05. 结论 磁化支架对犬PTCA术后冠状动脉再狭窄有显著的防治作用. 　　Keywords:coronary diseaseangioplasty，transluminal，per-cutaneous coronarymagnetic stentcoronary vessels/injury 　　Abstract:AIM To investigate the preventive effect of mag-netic stent on coronary restenosis after percutaneous translu-minal coronary angioplasty（PTCA）.METHODS Twenty dogs were randomly distributed to control and experimental groups，each of10dogs.Common Palmaz-stents in6-8seg-ments of left anterior descending or11-14segments of left　circumflexus，were implanted into the control dogs and mag-netic stents were implanted into the same parts of coronary arteries of the experimental dogs.All the dogs did not take any antiplatelet and anticoagulant before and after the opera-tion.6months later20dogs underwent coronary angiogra-phy，then put to death and3cm target vessel was taken from each dog for pathological examinations.RESULTS Three dogs in the control were overtaken with more than50%restenosis，but no one in the experimental group suffered restenosis.Average thickness of tunica intima was（2.98±0.56）mm in the control and（1.13±0.41）mm in the experi-mental group（0.05）.CONCLUSION Magnetic stent could significantly prevent coronary restenosis after PTCA. 　　0 引言 　　经皮冠状动脉腔内成形术（Percutaneous trans-luminal coronary angioplasty，PTCA）后冠状动脉再狭窄（Coronary restenosis，CRS）一直是冠心病介入治疗的一大并发症，严重影响着PTCA支架术的疗效，已成为国内外介入治疗领域研究的重点［1，2］ .目前有关防治CRS的文献较多，但所提出防治措施的疗效均未能显著降低CRS发生率（15%～20%）［1-3］ .基于磁场治疗能扩张血管，减轻血管内膜炎症反应，促进冠状动脉内膜覆盖，抑制动脉平滑肌细胞（Arterial smooth muscle cells，ASMCs）过度增殖的