FDA批准药物溶出方法数据库.xlsVIP

Sheet3 Sheet2 Sheet1 Tier I: 0.05 M Na phosphate buffer, pH 7.5 + 2% SDS (w/w) Tier II: 0.05 M Na phosphate buffer, pH 7.5 (700ml) + 1% pancreatin. After 15 min. incubation, add 200 mL of phosphate buffer containg 9% SDS? Zolmitriptan Tablet Orally Disintegrating)? Zolpidem Tartrate 1, 3, 5, 7, 10 and 15? Zonisamide Capsule?? 50?? 10, 20, 30 and 45??? Water (deaerated)?? 0.5, 2, 4, 6 and 8 hours?? Fluvoxamine Maleate 1, 2, 4, 6, 8 and 12 hours? Fosamprenavir Calcium 10 mM HCl? 5, 10,15 and 20? 250 mM Sodium Acetate/Acetic acid buffer pH 3.5? Fosinopril Sodium Fosinopril Sodium/Hydrochlorothiazide Frovatriptan succinate Phosphate Buffer pH 5.5? Furosemide Gabapentin Gabapentin Enacarbil 10 mM Phosphate buffer at pH 7.4 with 1.0 % SLS? 500 (for 300 mg); 900 (for 600 mg)? 0.5, 1, 2, 4, 6, 8, 12 and 24 hours? Galantamine HBr 50 mM potassium dihydrogen phosphate buffer pH 6.5 Comparative dissolution data should also be provided in 900 ml pH 0.1 HCl, pH 4.5 buffer, and water using Apparatus II (Paddle) at 50 RPM.? 1, 4, 10 and 12 hours? Ganciclovir 02/02/2004? Gefitinib Tween 80 (5% v/v) in water? Gemfibrozil Gemifloxacin Mesylate Glimepiride Phosphate Buffer, pH 7.8? 07/23/2004? Glimepiride/Pioglitazone HCl For Pioglitazone: pH 2.0, HCl Buffer. For Glimepiride: pH 6.8, Sodium Phosphate Buffer with 0.2% sodium dodecyl sulfate? For Pioglitazone: 10, 15, 20, 30 and 45; For Glimepiride: 10, 15, 20 and 30? Glimepiride/Rosiglitazone Maleate 0.01 M HCl with 0.5% Sodium Dodecyl Sulfate? 5, 10, 15, 30, 45 and 60? Glipizide Simulated Intestinal Fluid without pancreatin, pH 7.5? 1, 2, 4, 8, 16 hours and until at least 80% dissolved? Glipizide/Metformin HCL 12/18/2008? Glyburide (Micronized) Glyburide (Non-micronized) 0.05 M Borate Buffer, pH 9.5? Glyburide/Metformin HCl Glycopyrrolate Goserelin Acetate Implant? Prior to sampling, the jar is removed from incubation and mechanically swirled with digital orbital shaker? Swirl orbit of 50 mm at 205 rpm for 6 seconds? Each implant shoul