CELL DEATH课件.ppt

NECROSIS Three pattern of nuclear changes Morphologic appearance of necrosis TYPES OF CELL DEATH Gangrene A subtype of coagulation necrosis Dry gangrene Wet gangrene Gas gangrene Liquefactive necrosis Bacterial or fungal infections Central nervous system Amebiasis Fat necrosis Traumatic Activated pancreatic lipases Fibrinoid degeneration Deeply eosinophilic Collagen diseases Necrotic vasculitis Malignant hypertension MORPHOLOGICAL FEATURES OF APOPTOSIS Fig 1-18 Biochemical features of apoptosis Fig 1-19 Apoptosis-associated genes bcl-2, c-myc, p53 Fig 1-20 Section BFibrous RepairGranulation tissues: Granulation tissues Fig 4-14 Fig 4-15 Fig 4-18 Fig 4-19 Liquefactive necrosis Bacterial or fungal infections Central nervous system Amebiasis Fat necrosis Traumatic Activated pancreatic lipases Systemic factors influencing wound healing: Nutrition Metabolic status Circulatory status Hormones Infection Mechanical factors Foreign bodies Size, location and types of wound Local factors influencing wound healing: 79 80 81 82 83 85 86 87 88 89 90 71 91 92 93 94 95 97 98 100 102 103 104 3. DNA breakdown: 50-300 kb pieces Ca2+, Mg2+ dependent endonucleases DNA oligonucleosomes DNA ladders (also seen in necrosis) 4. PHAGOCYTIC RECOGNITION Receptors on macrophages for the surface components (phosphatidylserine, thrombospondin) on apoptotic bodies. Absorption Discharge: Erosion Ulcer Sinus Fistula Cavitation Organization Encapsulation Calcification Fates of necrosis Regeneration: Completely regeneration Fibrous repair Chapter Three Repair Section A Labile cells Stable cells Permanent cells Regeneration capacity 1. Cell-cell interaction Conditioned medium Contact inhibition 2. Extracellular matrix Laminin: ? Epithelia ? Fibroblasts Fibronectin : ? Epithelia ?Fibroblasts 3. Growth factors Factors influencing regeneration GROWTH FACTORS EGF, TGF-A, PDGF, aFGF, bFGF,