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A team of scientists and clinicians at UC San Francisco has discovered how to detect abnormal brain rhythms associated with Parkinsons by implanting electrodes within the brains of people with the disease. The work may lead to developing the next generation of brain stimulation devices to?alleviate(减轻,缓和)?symptoms for people with the disease.
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Described this week in the journal Proceedings of the National Academy of Sciences (PNAS), the work sheds light on how Parkinsons disease affects the brain, and is the first time anyone has been able to measure a quantitative signal from the disease within the?cerebral cortex(大脑皮层)?-- the outermost layers of the brain that helps govern memory, physical movement and consciousness.
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Normally the individual cells of the brain are functioning independently much of the time, working together only for specific tasks, said neurosurgeon Philip Starr, MD, PhD, a professor of neurological surgery at UCSF and senior author of the paper. But in Parkinsons disease, he said, many brain cells display excessive synchronization, firing together inappropriately most of the time.
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They are locked into playing the same note as everyone else without exploring their own music, Starr explained. This excessive?synchronization(同步,同时性)?leads to movement problems and other symptoms characteristic of the disease.
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The new work also shows how deep brain stimulation (DBS), which electrifies regions deeper in the brain, below the cortex, can affect the cortex, itself. This discovery may change how DBS is used to treat Parkinsons and other neurologically based movement disorders, and it may help refine the technique for other types of treatment.
在加州大学旧金山分校的科学家和临床医生的一个研究小组发现如何与帕金森氏症相关的疾病的人的大脑内植入电极来检测异常的脑节律。这项工作可能导致开发下一代的脑刺激器缓解(减轻,缓和)的症状与疾病的人。
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在国家科学院的科学(PNAS)杂志上的论文中描述这个星期,工作流光帕金森氏症影响大脑如何,以及是第一次有人已经能够测量大脑皮质内的一个定量的疾病信号(大脑皮层)?-大脑的最外层,有助于治理内存,物理运动和意识。
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“通常情况下,个别脑细胞是独立运作的大部分时间,只对特定的任务一起工作,说:”神经外科医生菲利普·斯塔尔博士,加州大学旧金山分校神经外科教授和资深作者的论文。但是,在帕金森氏病,他说,许多脑细胞显示
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