Ebp1在肿瘤增殖和侵袭中的研究进展.pdfVIP

1536 中国肿瘤临床2014年第41卷第23期 Chin J Clin Oncol 2014,Vol.41,No.23 · · 国家基金研究进展综述 Ebp1在肿瘤增殖和侵袭中的研究进展* 刘 媛 张 飞 牛瑞芳 摘要 肿瘤细胞的恶性增殖和浸润转移是影响肿瘤发展和治疗效果的重要因素，了解调控增殖和转移的影响因子及其分 子机制对肿瘤早期的诊断和临床治疗意义重大。本文系统总结了增殖相关蛋白PA2G4（proliferationassociated2G4）家族成员 Ebp1在多种肿瘤中的表达情况及其对细胞周期、细胞凋亡和分化、细胞迁移等方面的影响，并归纳了Ebp1影响肿瘤增殖和迁移 的分子机制。Ebp在多种肿瘤中表达降低且与肿瘤的增殖和迁移呈负相关，并主要通过抑制周期相关蛋白的转录、调控影响肿瘤 发展的信号通路。 关键词 Ebp1 肿瘤进展 增殖 细胞周期 侵袭 doi:10.3969/j.issn.1000-8179 Development of Ebp1 in tumor proliferation and invasion Yuan LIU, Fei ZHANG, Ruifang NIU Correspondence to: Ruifang NIU; E- mail: niuruifang@ Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin 300060, China This work was supported by the Natural Natural Science Foundation of China (Nos.and Abstract This work summarizes the research development and molecular mechanism of Ebp 1, a member of the proliferation-associated 2G4 family, in tumor proliferation and invasion. This research serves as a basis and support for further research on the mechanism of tumor proliferation and invasion. The low expression of Ebp1 in various cancers promotes tumor proliferation and invasion. Ebp 1 inhibits E2F 1, cyclin D1, and cyclin E transcription by interacting with Rb, human histone deacetylase 2, and the transcriptional repressor Sin3A. This inhibition triggers cell cycle arrest and suppresses cell proliferation. Ebp 1 also influences cancer invasion and migration. However, the underlying mechanisms remain unknown and require further exploration. Keywords: Ebp 1, tumor progression, proliferation, cell cycle, invasion 近些年来肿瘤的发病率和死亡率日益增加，成 调节其在细胞内定位的决定因素。Ebp1的晶体结构