辅助生殖技术中卵巢过度刺激综合征发生发展预测指标的研究_李志凌.pdfVIP

2004 3 20 3 ·161 · 　 :1005-2216(2004)03-0161-03 李志凌　林　虹　肖婉芬　王玉莲 【　】　　寻找辅助生殖技术(ART)中卵巢过度刺激综合征(OH )发生发展 预测指标。 　比较 1998～2003 年ART 治疗后45 例OH 和 40 例非OH 患者 妊娠结局;并根据OH 发生时间分早发、晚发 两组, 比较组间特征和实验室资料, 回归分析筛查OH 发生发展预测指标。　HCG 注射后发生 OH 平均时间为(9.3±4.7)d。 早发组(尤合并妊娠者)比晚发组年轻、促性腺激素用量少、多囊卵巢病例多、HCG 注 射日中小卵泡评分高, 差异有显著性意义。回归分析发现:仅中小卵泡评分与OH 发生时间相关;用中小卵泡 评分20 分预测早发组OH 发生 阳性、阴性预测值, 敏感性、特异性分别为 90.0%、92.0%、81.8%、95.8%。 OH 持续时间与是否妊娠或多胎妊娠有关, 用OH 持续时间7d、≤7d、≥12d 可分别预测早发组妊娠、晚发 组未孕和多胎妊娠。　早发OH 与卵巢对外源性HCG 过度反应有关, HCG 日中小卵泡评分可预测OH 发生;晚发OH 更多与胚胎种植后产生 内源性HCG 有关, OH 持续时间可判断妊娠情况。 【】　辅助生殖技术　卵巢过度刺激综合征 :R71　　:A Study of predictive parameters of patients w ith ovarian hyperstimul ation syndrome developed during assi sted reproduc- tive technique.　　L i Zhiling, Lin Hong, Xiao Wanf en, et al.TheRep roductiveCenter, theFirst Aff iliated Hospital of Shantou University Medical College, Shantou 51504 1, China Abstract　Objective　To identify the predictive parameters of patients with ovarian hyperstimulation syndrome developed dur- ing assisted reproductive technique(ART).Methods　The pregnancy outcomes were compared between 45 cases of OH and 40 non-OH .Then the OH group was divided into early and late OH according to the onset time of OH .We compared patient s characteristics and laboratory data, and selected the predictive parameters related to OH onset and development by logistic regression.Results　OH occurred (9.3±4.7)days after the administration of HCG.Early OH (especially compli- cated pregnancy)occurred to younger patients with fewer gonadotropin requirements, higher polycystic ovaries and middle and