Considerations for Exposure to Diazinon and Chlorpyrifos.pptVIP

Considerations for Exposure to Diazinon and Chlorpyrifos Clement E. Furlong, PhD Research Professor Departments of Medicine (Div. Medical Genetics), and Genome Sciences University of Washington, Seattle, WA 98195-7720 clem@u.washington.edu Detoxicaton of OP Insecticides The commonly used organophosphorus insecticides parathion, chlorpyrifos and diazinon are manufactured as organoposphorothioates. These compounds are very poor inhibitors of cholinesterases. In organisms (target and non-target) the thioate is converted to an oxon form by cytochromes P450. Also, as discussed below, actua