HIVCellular Pathogenesis II.pptVIP

HIVCellular Pathogenesis II Benhur Lee, M.D. Nef Major determinant of pathogenicity in vivo nef-deleted SIV is severely attenuated in the rhesus macaque model infection of macaques with recombinant SIV carrying a premature STOP codon (point mutation) results in rapid revertants with the nef ORF Patients infected with nef-defective HIV have a dramatically decreased rate of disease progression (15 years) nef-deleted HIV do not deplete thymocytes as much, or replicate to as high titers, as wild-type HIV in the SCID-hu mice model Pleiotropic Functions of Nef Down-regulates cell surface level