复方丹参滴丸对人肝脏药物代谢酶CYP1A2活性的影响.pdfVIP

·中药临床· 中图分类号 R283．64；R975+．5文献标识码 A 文章编号 1001—0408(2008)15-1182-03 摘要 目的：研究复方丹参滴丸对人肝脏药物代谢酶CYPIA2活性的影响，指导临床合理用药。方法：采用反相高效液相色谱法 物代谢酶CYPlA2活性的变化。结果：受试者用药前CYPlA2的平均活性为4．20±1．54，服用复方丹参滴丸14d后CYPIA2的 平均活性为4．26±1．95，用药28 代谢药物的疗效。 关键词复方丹参滴丸；人肝脏药物代谢酶CYPlA2；咖啡因代谢物；反相高效液相色谱法 Effectof Danshen Pillson CYPlA2 CompoundDripping CytochromeActivity WU Central ofZibo Limited Hui(The 255120，China) Hospital MiningIndustryGroup Company，Zibo CHEN Central 255031，China) Zuo—zhong(ZiboMunicipalHospital，Zibo PENG ofLife Xiang—qian(CollegeScience，LiaochengUniversity，Liaocheng252059，China) ZHANG Provincial Jian(ShandongHospital，Jinan250021，China) ABSTRACTOBJECTIVE：Totheeffectof danshen on CYPlA2for investigate Compounddrippingpillscytochromeactivity referenceofclinicalrationaluse．METHODS：Thecontentsoffour metabolitesof drug major acid(1U)and after theurinebeforeand oraladministrationof danshen weredeterminedRP—HPLC． (17u)in Compounddrippingpills by The of CYPlA2wasderivedfromtheratio activitycytochrome averageactivity ofCYPlA2was4．20±1．54before stoodat4．26±1．9514 4．35±1．26at28 medi． medication。which at and after days days 1．42％and therewasno differenceaftermedicationas withbefore cation，up 3．57％，respectively，yetsignificant compared medication．CONCLUSION：NodifferencewasnotedonCYPlA2 afteroralmedicationof significant activity Compound dan