局灶节段性肾小球硬化大鼠TGF-β1的表达及缬沙坦与罗格列酮的干预作用.pdfVIP

880 1的表达及 局灶节段性肾小球硬化大鼠TGF一13 缬沙坦与罗格列酮的干预作用木 张碧丽李志军宋兰云张碹王文红 摘要 格列酮干预治疗对其影响。方法：采用一侧肾切除加重复尾静脉注射阿霉素法建立局灶节段性肾小球硬化大鼠模 h 型。随机分为正常对照组、缬沙坦治疗组、罗格列酮治疗组、缬沙坦与罗格列酮联合治疗组及模型组。动态检测24 h 尿蛋白定量(24UP)及血生化值，计算内生肌酐清除率(Ccr)；对肾组织进行病理形态学观察，计算肾小球硬化指数 hUP降低，总蛋白、白蛋 TGF—Bl水平与SI、ECM／GA的相关性。结果：实验8周时各治疗组与模型组比较均显示24 或P0．01 疗效评估指标。缬沙坦、罗格列酮均可能成为防治FSGS的不同靶点，缬沙坦与罗格列酮组合可以作为FSGS非激素 治疗时联合用药的选择之一。 关键词降血糖药缬氨酸转化生长因子B大鼠 EffectsofValsartanand on of inFocal RosiglitazoneExpressionTGF-pl Segmental GIomerulosclerosisRats ZHANG Bili，LI Xuan，WANG Zhijun，SONGLanyun，ZHANG Wenhong Children’5 300074，China DepartmentofNephrology,TianjinHospital,Tianjin Abstract theeffectsofvalsarmnand on of in tissue TGF-131 Objective：Toinvestigate msiglitazoneexpression kidney offocal modelofFSGSwaaconstructedwithoneside glomemlosclerosis(FSGs)rats．Methods：Rat segmental nephrectomy and of wererandomizedtonormalcontrol injectionadriamycincaudal-venouslyrespectively．Rats treatmentandmodel hours andblood group，msiglitazene-treatedgroup，integratedgroup group．Twenty—foururinaryprotein biochemicalindicatorsweremeasuredatthe and8thweek．Thevaluesofcreatinine calculat