cjoc 金属催化的2_5H_呋喃酮反应研究进展.pdfVIP

2011 年第31 卷 有 机 化 学 Vol. 31, 2011 第9 期, 1377～1387 Chinese Journal of Organic Chemistry No. 9, 1377～1387 ·综述与进展· 金属催化的 2(5H)-呋喃酮反应研究进展 毛超旭 汪朝阳* 谭越河 薛福玲 (华南师范大学化学与环境学院 广州 510006) 摘要 2(5H)-呋喃酮结构单元广泛存在于天然产物中, 同时许多 2(5H)-呋喃酮类化合物也是重要的有机合成中间体. 因此, 基于常见 2(5H)-呋喃酮的有机合成研究近年来引起了人们的关注, 尤其是金属催化的 2(5H)-呋喃酮反应的地位 日趋彰显重要, 从而成为众多化学工作者的研究热点. 按照反应类型的不同, 对近年来金属催化的 2(5H)-呋喃酮反应 的研究进展进行了综述, 主要包括Sonogashira, Suzuki, Stille 等偶联反应, 以及Michael 加成反应、Friedel-Crafts 烷基化 反应、Baylis-Hillman 反应、亲核取代反应、还原反应等. 关键词 2(5H)-呋喃酮; 金属催化; 偶联反应; Sonogashira 反应; Suzuki 反应; Michael 加成反应 Recent Progress in Metal-Catalyzed Reactions of 2(5H)-Furanones Mao, Chaoxu Wang, Zhaoyang* Tan, Yuehe Xue, Fuling (School of Chemistry and Environment, South China Normal University, Guangzhou 510006) Abstract The unique carbon skeleton of 2(5H)-furanone is widely present in a variety of natural products, and many compounds containing 2(5H)-furanone skeleton are important synthetic intermediates. Recently, more and more attentions have been attracted to the organic synthesis based on 2(5H)-furanones, especially via the metal-catalyzed reactions of 2(5H)-furanones. Classified as different types, the recent progress in metal-catalyzed reactions of 2(5H)-furanones, mainly including Sonogashira reaction, Suzuki reaction, Stille reaction, Michael addition, Friedel-Crafts alkylation, Baylis-Hillman reaction, nucleophilic substitution, and reduction reaction, is reviewed in this paper. Keywords 2(5H)-furanone; metal-catalyzed; coupling reaction; Sonogashira react