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《转化医学电子杂志》论文模板 15-PGDH在食管癌中的表达特征及临床意义 刘震雄，秦明，赵曙光，王旭霞，王景杰 （中国人民解放军第四军医大学唐都医院消化内科，陕西 西安 710038） 探讨15-羟基前列腺素脱氢酶(15-PGDH)在癌中的表达及其与临床病理特征的关系，并初步评价其意义。随机收集例癌手术病人的癌组织及相应癌旁正常组织，应用免疫组织化学检测15-PGDH表达特征并进行评分，进一步分析15-PGDH的表达特征与食管癌临床病理参数关系。癌中15-PGDH的表达水平显著降低甚至缺失。临床病理学相关性统计分析，15-PGDH癌中15-PGDH的表达减少或缺失参与了食管癌的发生发展过程 【关键词】食管癌；15-羟基前列腺素脱氢酶；临床病理特征 【中图分类号】R735.2 （可登陆网站查询/）【文献标识码】A Expression and clinical significance of 15-hydroxyprostaglandin dehydrogenase in esophagus cancer LIU Zhen-xiong, Qin Ming, Zhao Shu-guang, WANG Xu-xia, WANG jing-jie (Department of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xi’an, 710038, China） 【ABSTRACT】Objective:To investigate the expression and clinical significance of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) protein in esophagus cancer. Methods: Immunohistochemistry was used to detect the expression of 15-PGDH protein in 66 esophagus cancer tissues and adjacent non-tumor tissues. Statistic analyses were explored to value its relation with the clinicopathological parameters. Results:15-PGDH expression was found decreased or even absent in esophagus cancer tissues compared with the corresponding non-tumor tissues. Further analysis about its relationship with clinicopathological parameters revealed that the downregulated of 15-PGDH was significantly related with differentiation grade, TNM stage and lymph node metastasis. Conclusions:The expression of 15-PGDH is decreased or even absent in esophagus cancer tissues. The results suggest that 15-PGDH may be an important indicator in carcinogenesis and progression of esophagus cancer. 【Key words】Esophagus cancer; 15-hydroxyprostaglandin dehydrogenase (15-PGDH); clinical pathologic parameters _________________________ 收稿日期：2013-11-12；接受日期：2013-1 基金项目：基金类别（基金编号：）[没有则不用填写] 作者简介：姓名（1975-），性别，学历，职称，研究方向：Tel，E-mail：。 通讯作者：姓名，E-mail:？ 0 引言 食管癌是最常见的恶性肿瘤之一，严重威胁人类的生命健康近年研究显示，5-羟基前列腺素脱氢酶(15-hydroxyprostaglandin dehydrogenase, 15-PGDH)是在癌、癌、结肠癌等多种肿瘤中低表达，而恢复其表达则能抑制肿瘤的生长及转移，提示15-PGDH可能起