氟比洛芬酯超前镇痛对患者术后自控镇痛效果的影响.docVIP

氟比洛芬酯对患者镇痛 【摘要】目的　氟比洛芬酯对开胸术后患者自控静脉镇痛( PCIA)方法　48例开胸手术患者,随机分为观察组和对照组,各24例。观察组在术前15 min及关闭胸腔前分别静注氟比洛芬酯50 mg对照组静注等量两组术毕芬太尼PCIA术后2、8、16、24 h随访疼痛视觉模拟评分(VAS)镇痛期间芬太尼用量镇痛泵有效按压次数。结果 观察组24 h芬太尼用量49.5±2.6）ml明显少于对照组66.2±3.3 )ml( P0.05) ；观察组患者PCIA有效按压次数0.6±0.3)?单位明显少于对照组2.1±1.3 ）？单位( P0.05) ；观察组术后1 、2 、4 、8、24 h VAS2.7±0.3）、（2.2±1.1）、（1.8±0.4）、（1.3±0.3）分 显著高于对照组3.6±1.5）、（3.1±0.9）、（2.8±0.5）、（2.4±0.7）分 (均 P0.05)。结论　氟比洛芬酯可有效开胸手术患者镇痛效果,能明显减少PCIA芬太尼用量。 【关键词】镇痛控胸手术氟比洛芬酯 Preemptive Analgesic Effects of Flurbiprofen Axetil on Patient – Controlled Intravenous Analgesia with Fentanyl in Thoracic Patients 【Abstract】Objective To observe the preemptive analgesic effects o f flurbiprofen axeil on patient - controlled in travenous analgesia ( PC IA) with fentanyl in patients received thoracsurgery. Methods 48 patien ts (ASA Ⅰ～Ⅱ) were randomly assigned two groups: study group(n = 24) and control group (n = 24). Patients in study group received in travenous flurbipro fenaxeil 50mg 15m in before surgery and suture. Patients in both groups were given patient - controlled in travenous analgesia with 0. 001% fentanyl. PC IA recipe: loading dose fentanyl 1μg/Kg,contionuous infusions 2mL /h, PCA bolus 0.2mL, lockout time 15 m in. Visual analogue scale(VAS) of2, 8, 16, 24h were recorded. Pressing times and the demanding of fentanyl were a lso recorded. Results The differences of VAS after 2, 8, 16, 24h between two groups were significant (P0.05). The total demand of fentanyl within 24h in study group were less than that in control group (P0.05). Pressing time s of different time points in study group was much lower than that in control group (P0.05). Conclusion Preemtive flurbiprofen axeil can obviously improve the analgesic effects of PCIA with fentanyl in patients received tho racic surgery.The consumption of fentanyl can be decreased. 【Key words】nalgesia, patient-controlled；Thoracic surgical procedures； Flurbiprofen axeil （请按“中文摘要”内容，把“英文摘要”作相应修改） 超前镇痛旨在通过阻断从损伤组织至脊髓的神经向心束，从而避免了脊髓的长期致敏状态或因神经末梢受刺激而在脊