海洋寡肽预防去卵巢大鼠骨质疏松的研究.pdfVIP

中国食晶科学技术学会营养支持专业委员会 海洋寡肽预防去卵巢大鼠骨质疏松的研究 韩晓龙许雅君王军波裴新荣杨睿悦李勇 北京大学医学部营养与食品卫生学系，北京100083 摘要：目的观察海洋寡肽(BP)对去卵巢大鼠骨骼的影响。方法3)q龄雌性SD大鼠98只，随机分为假手 术组、去卵巢组和5个海洋寡肽组。海洋寡肽组大鼠行双侧卵巢去除术后，分别灌喂BP6，3，1．5，0．75， 增加。并且增加股骨的长度和横径。同时处死前体重、体重增加和子宫湿重无明显变化。结论：海洋寡肽 能有效预防去卵巢大鼠的股骨丢失，同时对子宫没有刺激作用。 关键词骨质疏松：海洋寡肽：去卵巢大鼠 Marine bonemass peptidepreserves biomechanicalin and ovariectomizedmice strength HAN XU WANG PEI YANG LI xiaolongyajnil junbo xinrong ruiyueyong ofnutritionandfood healthsciencecenter Department hygiene，pekinguniversity to the effectsofmarine onthe ofboneloss Abstract：Objectiveinvestigateinhibitory peptide progress induced femaleratswere 4sham into byovariectomy．Methodseighty-four ovariectomized，1operated，divided six of14 onlowcalcium treatedeitherwithvehicleormarine groupseach，fed diet(0．04％Ca)and peptide(6，3， a 90 tOsham animals 1．5，0．75，O．325mg／kgbodyweight，twiceday)fordays．Results rats，OVX Compared showedandecreaseinfemoral andbonemineral were diameter,length density(BMD)which significantly reversedinmarine treatedanimals．Whiletherewereno differencesin peptide significant weightgainamong inuterine intheOVXanimals thatthe reduction indicated wassuccessful． groups．And weight