血浆一氧化氮水平与支气管哮喘的相关性研究.docVIP

论　　著??Lunzhu　　《中国医学创新》第?9?卷?第?9?期（总第?219?期）2012?年?3?月 血浆一氧化氮水平与支气管哮喘的相关性研究* 陈嘉馨①　陆家政②　黎惠贞①　吴荣华①　杜一凡②　麦燕瑜①　臧林泉② 　　【摘要】　目的?：观察支气管哮喘患者血浆一氧化氮水平的变化，研究其与支气管哮喘的相关性。方法?：将?70?例支气管哮喘患者分为哮喘 缓解期组?30?例，轻度急性发作期组?10?例，中度急性发作期组?12?例，重度急性发作期组?18?例?；正常对照组?15?例，采用硝酸还原酶法测定血 浆一氧化氮水平并检测肺功能和测定诱导痰细胞的计数及分类。结果?：支气管哮喘患者的血浆一氧化氮水平显著高于正常对照组?(P0.01)，其 中急性发作期组显著高于缓解期组?(P0.01)，急性发作期组中轻度、中度、重度三者之间比较差异均有统计学意义?(P0.01)。线性相关性分析 显示，一氧化氮水平与支气管哮喘发作有相关性。研究对象所处的状态?(健康、哮喘缓解期及哮喘发作期?)?与血浆一氧化氮水平明显相关?(r=0.786， P0.01)。急性发作期患者血浆一氧化氮水平与?FEV1.0%?预计值?(r=-0.872，P0.01)?和诱导痰巨噬细胞百分比?(r=-0.820，P0.01)?呈负相关?；与 诱导痰细胞总数、中性粒细胞百分比及诱导痰嗜酸细胞百分比呈正相关?(?分别为?0.857、0.816?和?0.825，P0.01)。结论：血浆一氧化氮水平升高， 与支气管哮喘发生、发展相关，可能参与哮喘的发病，内源性一氧化氮作为一种无创性指标监测疾病的严重程度和活动度具有一定意义。 　　【关键词】　一氧化氮?；　支气管哮喘?；　诱导痰 　　Study?on?the?Effect?of?the?Plasma?Level?of?Nitric?Oxide?on?Patients?with?Acute?Asthma/CHEN?Jia-xin，LU?Jia-zheng，LI?Hui-zhen，et al.//Medical?Innovation?of?China，2012，9(9):6-8 　　【Abstract】　Objective?：To?investigate?the?effect?of?nitric?oxide(NO)?on?patients?with?asthma.?Methods?：Levels?of?serum?NO(nitrate?reductase method)，lung?function，and?cell?differential?count?in?induced?sputum?were?studied?in?40?patients?with?acute?exacerbation?of?asthma，30?patients?with stable?asthma?and?15?health?subjects.?Results?：The?serum?NO?level?was?(43.28±4.06)?μmol/L?in?control?group(15?cases)，(56.30±3.07)?μmol/L?in patients?with?stable?asthma(30?cases)，(65.57±2.38)?μmol/L?in?patients?with?mild?of?acute?exacerbation?asthma(10?cases)，(71.73±6.08)?μmol/L?in?that with?moderate?of?acute?exacerbation?asthma(12?cases)，and?(87.36±7.15)?μmol/L?in?that?with?severe?of?acute?exacerbation?asthma(18?cases).?Status?of?the subjects(in?health，stable?asthma，and?exacerbation?of?asthma)?was?positively?correlated?with?NO?in?serum(r=0.786，P0.01).?NO?in?serum?with?severe?of acute?exacerbation?asthma?was?negatively?correlated?with?FEV1.0%(r=-0.872，P0.01)?and?the?percentage?of?sputum?macrophages?(r=-0.820，P0.01). While?it?was?positively?correlated?with?total?count?of?sputum?cells(r=0.857，P0.01)，t