颈动脉灌注红花注射液治疗急性脑梗死的疗效观察_医学论文.docVIP

颈动脉灌注红花注射液治疗急性脑梗死的疗效观察_医学论文 颈动脉灌注红花注射液治疗急性脑梗死的疗效观察_医学论文 作者：徐开蕾，范华昌，沈文英，刘龙民，黄太权 【摘要】 目的 探讨颈动脉灌注红花注射液治疗急性脑梗死的临床疗效。方法 将100例脑梗死患者随机分为红花注射液颈动脉灌注组(治疗组)50例和红花注射液静脉滴注组(对照组)50例，治疗组：于0.9%氯化钠注射液60ml中加入红花注射液20ml，以4ml/min的滴速经颈动脉灌注；对照组：以红花注射液20ml加入0.9%氯化钠注射液500ml中静滴，20天后对两组疗效进行分析并观察治疗前后肢体肌力及血液流变学变化。结果 治疗组总有效率为94.0%，优于对照组62.0%(0.01)。治疗后治疗组肌力及血液流变学改善明显优于对照组（0.05，0.01）。结论 中药红花注射液经颈动脉灌注治疗急性脑梗死的疗效优于静脉全身给药。 【关键词】 急性脑梗死 颈动脉灌注 红花注射液 中医药疗法 Curative effect observation of treatment in acute cerebral infartion by safflower injection via carotid artery infusion 【Abstract】 Objective To observe the clinical efficacy of treatment in acute cerebral infarction by Safflower injection via carotid artery infusion.Methods 100 cases were randomized into treatment group in which 50 cases were treated with Safflower injection via carotid artery infusion， added Safflower injection 20ml into 0.9% sodium chloride injection 60ml with the 4ml/min velocity， once a day control group in which 50 cases were treated with venous drip of Safflower injection， added Safflower injection 20ml into 0.9% sodium chloride injection 500ml. After therapy， the curative effect、 myodynamia and hemorrheology were compared between the two groups.Results The total effective rate was 94.0% in treatment group， was higher than 62.0% in control group (0.01). After therapy， myodynamia and hemorrheology in treatment group， was higher than control group (0.05，0.01).Conclusion The clinical efficacy of treatment in acute cerebral infarction by Safflower injection via carotid artery infusion was better than intravenous drip. 【Key words】 acute cerebral infarction carotid artery infusion safflower injection Chinese medicine 　　我国是脑血管病的高发区之一，近年来脑梗死的发病率呈上升趋势［1］，因此对脑梗死的治疗日益受到重视。寻找安全有效的新技术新方法，开拓中药给药新途径，提高脑梗死的疗效，是临床研究的重点。本文在上海市卫生局科学技术发展基金的支持下，开展了颈动脉灌注红花注射液治疗急性脑梗死的临床研究，现报告如下。 1 资料与方法 1.1 病例选择 选取的100例观察对象均为2001年9月～2004年4月由急诊收治的急性脑梗死患者，随机分为两组。治疗组50例，其中男28例，女22例；年龄44～80岁，平均(62.03±9.33)岁；治疗前病程4h～7天，平均(1.8±0.7)天；其中肌力0°32例，Ⅰ°6例，Ⅱ°9例，Ⅲ°3例；伴有高血压病30例，