原创力文档a prospective, multicenter evaluation of predictive factors for positive surgical margins after nephron-sparing surgery for renal cell carcinoma the record1 italian project论文.pdfVIP
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Original Study
A Prospective, Multicenter Evaluation of
Predictive Factors for Positive Surgical Margins
After Nephron-Sparing Surgery for Renal Cell
Carcinoma: The RECORd1 Italian Project
Riccardo Schiavina,1 Sergio Serni,2 Andrea Mari,2 Alessandro Antonelli,3
Riccardo Bertolo,4 Giampaolo Bianchi,5 Eugenio Brunocilla,1 Marco Borghesi,1
Marco Carini,2 Nicola Longo,6 Giuseppe Martorana,1 Vincenzo Mirone,6
Giuseppe Morgia,7 Francesco Porpiglia,4 Bernardo Rocco,8 Bruno Rovereto,9
Claudio Simeone,3 Mario Sodano,3 Carlo Terrone,10 Vincenzo Ficarra, 11
Andrea Minervini2
Abstract
The early oncological goal of any partial nephrectomy (PN) is to achieve negative surgical margins (SMs).
Several factors have been advocated as predictors of positive SMs (PSMs) after nephron-sparing surgery
(NSS). In our study, age, upper pole tumor location, standard PN and Fuhrman 3/4 nuclear grade were found to
be independent predictors of PSMs at multivariable analysis. Further evaluations are required to verify the
oncological effect of the PSM on local and systemic recurrence.
Background: The purpose of this study was to evaluate the predictors of positive margins in one of the largest
available prospective multi-institutional studies. Patients and Methods: We evaluated all patients who underwent
NSS for radiologically diagnosed kidney tumors between January 2009 and December 2012 at 19 urological Italian
centers (Registry of Conservative Renal Surgery [RECORd] project). Preoperative and anthropometric data, comor-
bidities, intraoperative and postoperative outcomes, and histolog
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