慢性肾病患者肾功能水平与血脂代谢的关系.docVIP

慢性肾病患者肾功能水平与血脂代谢的关系 杨 瑛 摘要：目的 探讨慢性肾病患者肾功能水平与血脂代谢的关系。方法 选取慢性肾衰CRF(29例)、慢性肾炎CN(21例)、糖尿病肾病DN(14例)、肾病综合症NS(12例)。以健康体检者65名作为正常对照（NC），检测肾功能、血脂、hsCRP、24小时尿蛋白排泄量各指标的关系。结果 CN组Urea、SCysC、hsCRP、LDL-C、LP(a)、24hr尿蛋白有显著升高；DN组Urea、Cr、β2MG 、SCysC、hsCRP、APOA1、LP(a) 、24hr尿蛋白有显著升高；NS组Urea、hsCRP、Tch、TG、HDL-C、LDL-C、APOB、LP(a)、24hr尿蛋白有升高；CRF组Urea、Cr、UA、β2MG、SCysC、hsCRP、TG、LDL-C、APOB、LP(a)、24hr尿蛋白均有显著升高。结论 肾病患者在肾功能指标发生改变的同时，伴随有血脂及hsCRP的改变。 关键词:慢性肾脏疾病;肾功能;脂质代谢 Relation of renal function and lipid metabolism in patients with chronic kidney disease ( YANG Ying .department of clinical laboratory,traditional Chinese medical hospital of Liyang city ,Jiangsu 213300,China) (tel) Email:yy801115@ [Abstract]:Objective To investigate the relationship between renal function and lipid metabolism in patients with chronic renal disease.Methods A total of 76 patients with chronic renal disease were enrolled and classified into chronic renal failure (29 cases,CRF group),chronic nephritis (21 cases,CN group),diabetic nephropathy(14 cases,DN group) and nephrotic syndrome (12 cases,NS group),and 65 healthy subjects were enrolled as healthy controls (NC group),the relationships between renal function,lipid metabolism,hsCRP and 24 hours urinary albumin excretion rate (UAER) were analyzed.Results Urea.SCysC.hsCRP.LDL-c.Lp(a).24h UAER were significantly higher in CN group;Urea, Cr, β2-MG, SCysC,hsCRP, ApoA1,Lp(a), 24h UAER were significantly higher in DN group; Urea, hsCRP,Tch, TG,HDL-c,LDL-c, ApoB,Lp(a),24h UAER were significantly highly in NS group; Urea,Cr,UA,β2-MG, SCysC, hsCRP,TG, LDL-c,ApoB, Lp(a),24h UAER were significantly higher in CRF group. Conclusions Accompany with the changes of renal function in patients with chronic renal diease,the lipid metabolism and hsCRP also have been changed. Key words: Chronic renal disease;renal function;lipid metabolism 自1982年Moorhead提出“脂质肾毒性”假说[1]，国内外许多学者相济研究后认为肾脏也是血脂异常危害的一个重要靶器官，血脂的代谢异常参与了肾病的发生和发展[2],但其脂质代谢紊乱的特点，各文献报道不一。我们对76例肾病患者的血脂、肾功能、hsCRP、2