howtoconductametaanalysis如何进行meta分析.pptVIP

How to Conduct a Meta-Analysis Arindam Basu MD MPH About the Author Required Browsing Objectives Following the course, you will be able to: Define Meta-analysis Select Studies for a Meta-analysis Identify different types of Models Calculate Summary Effects Interpret Results of a Meta-analysis What is Meta-analysis? Synthesis of previous studies Providing a Summary estimate Steps Identify studies Define Eligibility Criteria Abstract Data Do Statistical Analysis Identify Studies: Overview Steps: Search Your Personal Files First Search Electronic Databases Review Reference Lists of Articles Contact Experts and Researchers Retrieve New Articles Evaluate Quality of the Studies Set Up Eligibility Criteria Searching Electronic Databases First, Define a Search Strategy Limitations of Databases incomplete and imperfect queries language problems problems with fugitive literature Publication Bias is important What is publication bias How to deal with publication bias Evaluating Study Quality Define Study Quality Criteria Early Set Up A Good Scoring System Develop A Form for Assessment Calculate Quality for each Study Use this for Sensitivity Analysis stratify studies according to quality Defining Eligibility of Studies Select Eligible Studies Based On: Study Designs Years of Publication Language Choice among multiple articles Sample-size or follow-up issues Similarity of Exposure and/or Rx Completeness of information Abstract Data - Review! Steps: Identify Relevant Articles Sort out Eligible Articles Set up a Form for Abstraction Enter the Eligible Studies Use this as your database Statistical Analysis is next... Statistical Analysis - Overview Select An Estimate of Effect Choose An Effects Measure Select An Effects Model For Each Model: Calculate Summary Effect Size Calculate Confidence Intervals Calculate Q-statistic for Homogeneity Perform Sensitivity Analysis Selecting Estimate of Effect Choose Only One Estimate For RCTS, choose the one with Once rando